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Product Name:A-582941
CAS:848591-90-2
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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MQ (shanghai) Pharmaceuticals Co., Ltd.
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Product Name:2-Methyl-5-(6-phenylpyridazin-3-yl)octahydropyrrolo[3,4-c]pyrrole dihydrochloride
CAS:848591-90-2
Purity:＞95% Package:1G，5G
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BOC Sciences
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Product Name:A 582941
CAS:848591-90-2
Purity:≥98% by HPLC Remarks:A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively).
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| | A 582941 Basic information |
| Product Name: | A 582941 | | Synonyms: | A 582941;Pyrrolo[3,4-c]pyrrole, octahydro-2-Methyl-5-(6-phenyl-3-pyridazinyl)-, dihydrochloride;Pyrrolo[3,4-c]pyrrole, octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-, hydrochloride (1:2);A 582941; A582941;2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole:dihydrochloride;(3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole;Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole;A-582941 dihydrochloride | | CAS: | 848591-90-2 | | MF: | C17H21ClN4 | | MW: | 316.83 | | EINECS: | | | Product Categories: | | | Mol File: | 848591-90-2.mol |  |
| | A 582941 Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | <28.04mg/ml in DMSO; <14.02mg/ml in 1eq. HCl | | form | solid | | color | White |
| | A 582941 Usage And Synthesis |
| Uses | A 582941 has been shown to provide glycogen synthase kinase-3β activation and α7 nicotinic receptors in Aβ1-42-induced tau phosphorylation in PC12 cells, which is useful in neurodegeneration associated with Alzheimer''s disease research. | | Biological Activity | a 582941 is a highly selective partial agonist of α7 nicotinic acetylcholine receptors (nachrs), with an ec50 value of 4260 nm to human α7 nachrs [1].nachrs are a family of pentameric ligand-gated ion channels. they are derived from multiple α (α2-α10) and β (β2-β4) subunit genes. α7 nachr receptor exhibits higher ca2+ permeability than other nachr combinations. these receptors modulate the release of multiple neurotransmitters, including acetylcholine (ach), glutamate, and gaba [1].in flipr, a 582941 did not activate recombinant heteromeric nachrs (α4β2, α3β2, α3β4, or α4β4) according to ca2+ dynamics results. in imr-32 cells expressing native human α3β4 nachrs, a 582941 did not produce an agonist effect (with an efficacy less than 20% at concentrations up to 100,000 nm). in xenopus oocytes expressing an α9α10 nachr construct, a 582941 at concentrations up to 100,000 nm did not evoke currents. with respect to nachrs, a 582941 activated only the homomeric α7 subtype [1].in a rat model of short-term memory based on olfactory cues, saline-treated adults used investigation times during the second session nearly equal to the first session, exhibiting little recognition of the juvenile. treatment with a 582941 in adult rats resulted in a dose-related reduction in the exploration time during the second session compared with the first session, exhibiting improved recognition of the juvenile [1]. | | storage | Desiccate at RT | | references | [1]. tietje kr, anderson dj, bitner rs, et al. preclinical characterization of a-582941: a novel α7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties. cns neuroscience & therapeutics, 2008, 14(1): 65-82. |
| | A 582941 Preparation Products And Raw materials |
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