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Dexamethasone Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:Dexomethasone
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:50-02-2
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Products Intro: Product Name:Dexamethasone
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene3,20-dione
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Products Intro: Product Name:Dexamethason
Purity:99% Package:1KG;800USD
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: CAS:50-02-2
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Dexamethasone manufacturers

  • dexamethasone
  • US $0.00 / KG
  • 2019-10-31
  • CAS:50-02-2
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 1 ton
  • Dexamethasone
  • US $1.00 / g
  • 2019-08-01
  • CAS:50-02-2
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 5 Metric Ton/Metric Tons per Month
  • Dexamethasone
  • US $1.00 / KG
  • 2019-07-06
  • CAS:50-02-2
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Dexamethasone Basic information
Description Side Effects Drug Reactions
Product Name:Dexamethasone
Synonyms:-Methyl Prednisolone-d3 3,20-Dioxime;-Fluoro-21-hydroxy-16α-Methyl-20(R)-hydroxy Prednisolone 21-Acetate;-OL-20-ONE GLUCOSIDURONATE, SODIUM SALT;17-DIOL-20-ONE 3-SULPHATE SODIUM SALT;-OL ~78%;-DIOL-17-ONE;-OL-20-ONE ACETATE 20-OXIME
Product Categories:Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Steroid and Hormone;Pharmaceutical intermediate;API;MAXIDEX;Hormone Drugs;Mainly used for anti-inflammatory and allergy;Pharmaceuticals;Isotope Labeled Compounds;Pharmaceutical intermediates;pharmaceutical intermediate and medicine grade
Mol File:50-02-2.mol
Dexamethasone Structure
Dexamethasone Chemical Properties
Melting point 262-264 °C(lit.)
alpha 75 º (c=1, dioxane)
density 1.1283 (estimate)
refractive index 76 ° (C=1, Dioxane)
Fp 9℃
storage temp. 2-8°C
solubility ethanol: 1 mg/mL
form powder
color off-white
Water Solubility 10 mg/100 mL (25 ºC)
Sensitive Light Sensitive
Merck 14,2943
BRN 2066651
Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
CAS DataBase Reference50-02-2(CAS DataBase Reference)
NIST Chemistry ReferencePrednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
EPA Substance Registry SystemDexamethasone (50-02-2)
Safety Information
Hazard Codes Xi,Xn,T,F
Risk Statements 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11
Safety Statements 36/37-45-36-26-22-16
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 2
RTECS TU3980000
HS Code 29372210
Hazardous Substances Data50-02-2(Hazardous Substances Data)
ToxicityLD50 oral in rat: > 3gm/kg
MSDS Information
Dexamethasone Usage And Synthesis
DescriptionDexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cd k2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC50=5 nM). Dexamethasone regulates T cell survival, growth, and differentiation.Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
Side EffectsDexamethasone is a artificially synthetic glucocorticoid, belonging to a long-term glucocorticoid drugs. Glucocorticoids can promote the metabolism of the three major nutrients while preventing protein synthesis with long-term topical being able to causing more serious consequences. However, the adverse effects should be much smaller than oral medication. Common side effects of systemic corticosteroid include:
It can cause stomach discomfort and increased sensitivity to stomach ulcers.
It can Increase the appetite and results in a significant increase in body weight.
Potential patients with diabetes: glucose intolerance in patients with aggravating existing diabetes.
It can cause mental illness including personality changes, irritability, agitation, and mania.
It can be used for the long-term treatment of osteoporosis: pathological fractures (such as hip).
It can cause elevated liver enzymes, fatty liver degeneration (usually reversible).
For patients of nephrotic syndrome, applying long-term high-dose medication is likely to cause large side effects such as gastrointestinal ulcers and avascular necrosis. For treatment of nephrotic syndrome, it is better to apply prednisone acetate tablets.
Dexamethasone can be used for the treatment of high altitude cerebral edema and pulmonary edema. Upon climbing expeditions, people can apply it to alleviate altitude sickness.
Combination with marbofloxacin and clotrimazole, etc. can be used for treating the ear infection and allergies of a dog or a bird.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Drug ReactionsDexamethasone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.
Dexamethasone may react with these drugs:
Daunorubicin HCl
Doxorubicin HCl
Phenytoin sodium
Chemical PropertiesWhite or almost white, crystalline powder.
IndicationsCushing’s disease is defined as hypercortisolism due to chronic overproduction of corticotrophin by a corticotroph adenoma. Cortisol’s lack of suppressibility during the administration of low doses of dexamethasone but suppressibility during high-dose dexamethasone is the key diagnostic finding in 99% of the patients with Cushing’s disease. This contrasts with the lack of glucocorticoid suppressibility typically found in patients with corticotrophin-independent hypercortisolism (Cushing’s syndrome). A judicious selection of the available tests may be necessary to obtain an accurate diagnosis in patients with Cushing’s syndrome.
Brand nameAeroseb-Dex (Allergan); Decadron (Merck); Dexone (Solvay Pharmaceuticals); Hexadrol (Organon); Maxidex (Alcon); Mymethasone (Morton Grove).
General DescriptionOdorless white to off-white crystalline powder with a slightly bitter taste.
General DescriptionDexamethasone, 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione,is the 16 -isomer of betamethasone.
Dexamethasone acetate, USP (21-acetate)
Dexamethasone sodium phosphate, USP (21-sodiumphosphate).
Air & Water ReactionsInsoluble in water.
Reactivity ProfileDexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
Fire HazardFlash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.
Biological ActivityGlucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.
Safety ProfilePoison by intraperitoneal and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of F-.
Veterinary Drugs and TreatmentsGlucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intralesionally. The above listing is certainly not complete. For specific dosages and indications refer to the Doses section.
High dose dexamethasone use for shock or CNS trauma is controversial; recent studies have not demonstrated significant benefit and it actually may cause increased deleterious effects.
Purification MethodsDexamethasone has been recrystallised from Et2O or small volumes of EtOAc. Its solubility in H2O is 10 mg/100mL at 25o; and is freely soluble in Me2CO, EtOH and CHCl3. [Arth et al. J Am Chem Soc 80 3161 1958; for the -methyl isomer see Taub et al. J Am Chem Soc 82 4025 1960, see Beilstein 8 IV 3501.]
Dexamethasone Preparation Products And Raw materials
Preparation ProductsBECLOMETHASONE
Tag:Dexamethasone(50-02-2) Related Product Information
DEXAMETHASONE HEMISUCCINATE Fluocoutolone Hexanoate PARAMETHASONE ACETATE (200 MG) Paramethasone dexamethasone 21-methanesulfonate dexamethasone trimethyl acetate 6-BETA-HYDROXYDEXAMETHASONE Halometasone Flumethasone-17-acetate DEXAMETHASONE SODIUM PHOSPHATE DEXAMETHASONE, [6,7-3H]- DEXAMETHASONE 21-O-BETA-D-GALACTOPYRANOSIDE 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) Alclometasone 1,4-PREGNADIEN-11-BETA, 21-DIOL-3,20-DIONE 21-HEMISUCCINATE Dexamethasone Dexamethasone sodium phosphate Fluorine