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R428 Suppliers list
Tel: +undefined-21-51877795
Products Intro: Product Name:BGB324 (R428)
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Products Intro: Product Name:BGB-324
Purity:98% Min. Package:1G;100G;1KG;50KG Remarks:MC34135
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Products Intro: Product Name:R428
Purity:99% Package:25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
Products Intro: Product Name:Bemcentinib
Purity:As coa Package:As request Remarks:1037624-75-1
Company Name: Speranza Chemical Co., Ltd.
Tel: +86-86-075521030354 +8618688942810
Products Intro: Product Name:R428
Purity:98% Package:1KG;25KG

R428 manufacturers

  • R428
  • R428 pictures
  • $0.00 / 25KG
  • 2023-09-26
  • CAS:1037624-75-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000KG/month
  • R428
  • R428 pictures
  • $0.00 / 1KG
  • 2023-09-06
  • CAS:1037624-75-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500000kg
  • R428; R428 (BGB324)
  • R428; R428 (BGB324) pictures
  • $0.01 / 1KG
  • 2020-01-08
  • CAS:1037624-75-1
  • Min. Order: 1KG
  • Purity: 98%; 99%
  • Supply Ability: 1kg;10kg; 25kg
R428 Basic information
Product Name:R428
Synonyms:(S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine;BGB-324;BGB-324, CPDB1725;(S)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8;R428;R428 (BGB324);1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-1H-1,2,4-triazole-3,5-diamine;BGB324(R428,Bemcentinib)
Product Categories:Inhibitors;APIs;API
Mol File:1037624-75-1.mol
R428 Structure
R428 Chemical Properties
Melting point >211°C (dec.)
Boiling point 799.6±70.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form Yellow powder.
color Yellow
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
MSDS Information
R428 Usage And Synthesis
DescriptionR428 (bemcentinib, BGB324), a selective small-molecule inhibitor of AXL, is currently being evaluated in phase II trials for the treatment of non-small-cell lung cancer (NSCLC) and acute myelocytic leukemia (AML). It has been found to induce apoptosis in cancer cells and to block tumor spread in models of metastatic breast cancer. The therapeutic potential of R428 has also been demonstrated in highly invasive esophageal adenocarcinoma cells and in ESCC cells.
R428 is a selective, small molecule inhibitor of Axl that blocks its catalytic and precancerous activities. R428 treatment reduced Axl-induced AKT phosphorylation, cancer cell invasion, angiogenesis, and the production of pro-inflammatory cytokines. It also reduced the expression of the cytokine granulocyte macrophage colony-stimulating factor and Snail in a dosage-dependent manner. Interestingly,using R428 to inhibit Axl-mediated cellular and molecular functions during cisplatin treatments achieved an enhanced suppression of liver metastases. Axl knockdowns in RAC cell lines reduced migration, invasion, and in vivo engraftment, accompanied by a downregulation in the activity of the Ral GTPase proteins (RalA and RalB). Similar effects were obtained using an A428 inhibitor. Blocking Axl functions also abrogated the phosphorylation of ERBB2 (Her-2/neu) at the Tyr877 residue, which reveals the cross-functional effects of R428 on different receptor signaling axes.
Cabozantinib (XL184) and R428 (BGB324) Inhibit the Growth of Esophageal Squamous Cell Carcinoma (ESCC)
UsesR 428 is an AXL tyrosine kinase inhibitor shown to be used as an anti-cancer agent.
References1) Holland?et al.?(2010),?R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer;?Cancer Res.?70?1544 2) Fleuren?et al.?(2014),?The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma;?Oncotarget?5?12753 3) Xu?et al.?(2014),?Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma;?Biochem. Biophys. Res. Commun.?454?566 4) Ben-Batalla?et al.?(2017),?Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia;?Clin. Cancer Res.?23?2289 5) Lin?et al.?(2017),?Targeting AXL overcomes resistance to docetaxel therapy in advanced prostate cancer;?Oncotarget?8?41064 6) Guo?et al.?(2017),?Axl inhibition induces the antitumor immune response which can be further potentiated by PD-1 blockade in the mouse cancer models;?Oncotarget?8?89761 7) Ludwig?et al.?(2018),?Small-Molecule Inhibition of Axl Targets Tumor Immune
R428 Preparation Products And Raw materials
Raw materials1,2-Bis(bromomethyl)benzene
Tag:R428(1037624-75-1) Related Product Information
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