| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:CC0651
CAS:1319207-44-7
Purity:>98% Package:5115RMB/1mg
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| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:CC0651
CAS:1319207-44-7
Purity:>98% Package:5115RMB/1mg
|
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| Product Name: | CC0651 | | Synonyms: | L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-;CC0651;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;CC0651,CC-0651 | | CAS: | 1319207-44-7 | | MF: | C20H21Cl2NO6 | | MW: | 442.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1319207-44-7.mol |  |
| | CC0651 Chemical Properties |
| Boiling point | 755.7±60.0 °C(Predicted) | | density | 1.410±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 56 mg/mL (126.61 mM) | | pka | 3.37±0.34(Predicted) | | form | Powder |
| | CC0651 Usage And Synthesis |
| General Description | A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).
Please note that the molecular weight for this compound is batch-specific due to variable water content. | | Biochem/physiol Actions | Cell permeable: yes |
| | CC0651 Preparation Products And Raw materials |
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