| Company Name: |
SPIRO PHARMA |
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
|
| | TLN-4601 Basic information |
| Product Name: | TLN-4601 | | Synonyms: | TLN-4601;BU 4664L;DiazepinoMicin;ECO-4601;1,3,10-trihydroxy-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-11H-benzo[b][1,4]benzodiazepin-6-one;DIAZEPINOMICIN (TLN-4601;TLN-4601;ECO 4601;BU 4664L;ECO 04601;11H-Dibenzo[b,e][1,4]diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]- | | CAS: | 733035-26-2 | | MF: | C28H34N2O4 | | MW: | 462.58056 | | EINECS: | | | Product Categories: | | | Mol File: | 733035-26-2.mol |  |
| | TLN-4601 Chemical Properties |
| Melting point | 192-194 °C | | Boiling point | 693.2±55.0 °C(Predicted) | | density | 1.170±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.35±0.20(Predicted) | | color | Off-white to gray |
| | TLN-4601 Usage And Synthesis |
| Uses | Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1]. | | Definition | ChEBI: Diazepinomicin is a dibenzodiazepine with a farnesyl sidechain synthesized by Micromonospora sp.. It has a potent activity against a broad spectrum of tumor cell lines. It has a role as a cathepsin L (EC 3.4.22.15) inhibitor, an antioxidant and an antineoplastic agent. It is a dibenzodiazepine, a secondary amine, a farnesane sesquiterpenoid, a triol and an olefinic compound. It contains a 2-trans,6-trans-farnesyl group. | | References | [1] Campbell PM, et al. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal. 2010 Nov 2;5:18. DOI:10.1186/1750-2187-5-18 |
| | TLN-4601 Preparation Products And Raw materials |
|