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7,10-Dimethoxy-10-DAB III

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CAS:183133-94-0
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7,10-Dimethoxy-10-DAB III manufacturers

  • 7.10-Dimethoxy-10-DAB III
  • 7.10-Dimethoxy-10-DAB III pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:183133-94-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 7.10-Dimethoxy-10-DAB III
  • 7.10-Dimethoxy-10-DAB III pictures
  • $15.00 / 1KG
  • 2021-07-09
  • CAS:183133-94-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
7,10-Dimethoxy-10-DAB III Basic information
Product Name:7,10-Dimethoxy-10-DAB III
Synonyms:7β,10β-diMethoxy-10-deacetylbaccatin III;Cabazitaxel interMediate 1;7,10-MeO-10-DAB;7β,10β-Dimethoxy-10-dabⅢ;7β,10β-diMethoxy-10-DAB-II;(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe;7,1-DiMethoxy-1-DAB III;2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
CAS:183133-94-0
MF:C31H40O10
MW:572.64
EINECS:1592732-453-0
Product Categories:API;Intermediates;183133-94-0
Mol File:183133-94-0.mol
7,10-Dimethoxy-10-DAB III Structure
7,10-Dimethoxy-10-DAB III Chemical Properties
Melting point >225°C (dec.)
Boiling point 675.8±55.0 °C(Predicted)
density 1.31
storage temp. Sealed in dry,Room Temperature
solubility DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol
pka12.82±0.70(Predicted)
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
HS Code 29329990
MSDS Information
7,10-Dimethoxy-10-DAB III Usage And Synthesis
DescriptionCabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.
Uses4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
SynthesisSolvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.
Tag:7,10-Dimethoxy-10-DAB III(183133-94-0) Related Product Information
Dapoxetine 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid "7-(triMethylsilyl)-13-O-[((4S,5R)-2,4-diphenyl-4,5-dihydro oxazol-5-yl)carbonyl]baccatin Ⅲ 7-Troc-paclitaxel Cabazitaxel N-3 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III 2',3'-O,N-[(S)-(p-Methoxybenzylidene)]-7-O-(triethylsilyl)paclitaxel Deacetyltaxol 7-O-(TRIETHYLSILYL) BACCATIN III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid Cabazitaxel Docetaxel intermediate 10-Deacetylbaccatin III Paclitaxel Cabazitaxel N-1 (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Docetaxel