ChemicalBook > Product Catalog >API >Circulatory system drugs >Antihypertensive drugs >Telmisartan

Telmisartan

Telmisartan Suppliers list
Company Name: Jiangsu Zhongbang Pharmaceutical Co., Ltd.
Tel: 025-87151996
Email: zbsales@chinaredsun.com
Products Intro: Product Name:Telmisartan
CAS:144701-48-4
Purity:EP/ USP/ CP
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:Telmisartan
CAS:144701-48-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Telmisartan
CAS:144701-48-4
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:144701-48-4
CAS:144701-48-4
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:144701-48-4
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified

Lastest Price from Telmisartan manufacturers

  • Telmisartan
  • US $7.00 / kg
  • 2019-07-06
  • CAS: 144701-48-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg

Related articles

  • Telmisartan: uses & side-effects
  • Telmisartan oral tablet is a prescription drug that’s available as the brand-name drug Micardis. It’s also available as a gene....
  • Aug 19,2019
Telmisartan Basic information
Chemical Properties Mechanisms of Action Side Effects Patent
Product Name:Telmisartan
Synonyms:TU-199;TELMISARTAN;PRITOR;MICARDIS;BIBR 277;4'[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;4'-[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID;3-methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene
CAS:144701-48-4
MF:C33H30N4O2
MW:514.63
EINECS:620-494-7
Product Categories:Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;INTERMEDIATESOF;Antihypertensive;Imidazoles;(intermediates of telmisartan);Telmisartan;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Other Products;Hypertension.;CARADRIN
Mol File:144701-48-4.mol
Telmisartan Structure
Telmisartan Chemical Properties
Melting point 261-263°C
Boiling point 771.9±70.0 °C(Predicted)
density 1.16
RTECS DV2037500
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMSO: >5 mg/mL at 60 °C
form solid
pka3.86±0.36(Predicted)
color white
Water Solubility insoluble
Merck 14,9129
InChIKeyRMMXLENWKUUMAY-UHFFFAOYSA-N
CAS DataBase Reference144701-48-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 2
HS Code 2933995300
Hazardous Substances Data144701-48-4(Hazardous Substances Data)
Telmisartan Usage And Synthesis
Chemical PropertiesWhite or off-white crystalline powder, odorless and tasteless. Soluble in chloroform, slightly soluble in methanol, very slightly soluble in acetone, practically insoluble in water. Slightly soluble in 0.1mol/L hydrochloric acid, soluble in 0.1mol/L sodium hydroxide.
Absorption coefficient(E1%1cm):509~541
Mechanisms of Action80mg of telmisartan for the human body will practically completely counter the high blood pressure caused by angiotension II. Effects will last for 24 and can still be detected within 48 hours. Blood pressure-lowering effects should gradually become apparent within 3 hours after the initial dose. If treatment is suddenly interrupted, blood pressure will return to the same level as before treatment in a matter of days, and there will be no rebound high blood pressure. In a clinical trial that compared two kinds of antihypertensive drugs, patients in the treatment group experienced lower rates of coughing than those in the group treated by angiotensin converting enzyme inhibitors.
Telmisartan has a half-life of 18~24 hours, and will take effect 1~4 hours after taken. Medicinal effects can last for as long as 35 hours, with a high (T/P) ratio and outstanding effects in controlling morning blood pressure. Thus, this medicine can effectively control blood pressure for 24 hours, and it meets the once-daily medicinal standard (40~80mg, qd).
Clinical effects and characteristics:
  • Pharmacokinetics show: Rapid effects (0.3h), long duration (35.4h), little effect on heart rate when lowering blood pressure.
  • Compared to Enalapril: Stronger antihypertensive effects than Enalapril; when both are used in combination with diuretics, Telmisartan still appears to be superior and results in a lower coughing rate.
  • Compared to Lisinopril: More apparent antihypertensive effects (for both systolic and diastolic blood pressure), coughing rate for Telmisartan (16%) is drastically lower than that of Lisinopril (60%).
  • Compared to Atenolol: Similar antihypertensive effects, lower rate of side effects (impotence and fatigue).
  • Compared to Amlodipine: The Telmisartan group experienced noticeably lower heart rates four hours after ingestion and from six a.m. to twelve p.m.
Overall, Telmisartan has the following characteristics in comparison with other antihypertensive medicine: specific receptor effects, noticeable hypertensive effects, good diuretic effects, improvement of myocardial stenosis, safe usage, good tolerance, and convenient daily dosage.
Side EffectsIn the placebo control experiment, the incidence rate of negative events for the Telmisartan group (41.4%) was similar to that of the placebo group (43.9%). Negative events were unrelated to dosage, sex, age, or race.
The following lists negative reactions were accumulated via the 5788 hypertensive patients that were treated with Telmisartan in the clinical trial.
Negative effects are categorized by incident rate as:
Very common (>1/10); common (>1/100, <1/10=); uncommon (>1/1000, <1/100=); rare (>1/10000, <1/1000=); very rare (<1/100000=)
Bodily reaction: Common: Back pain (e.g. sciatica), chest pain, flu-like symptoms, infection symptoms (e.g. urinary tract infection including cystitis). Uncommon: sight abnormality, sweating.
Central and peripheral nervous system: Common: vertigo.
Digestive system: Common: stomach pain, diarrhea, indigestion, gastrointestinal disorders. Rare: dry mouth, bloating.
Muscle skeletal system: Common: joint pain, leg cramps or leg pain, muscle pain. Rare: Tenosensitis symptoms.
Nervous system: Rare: anxiety.
Respiratory system: Common: upper respiratory tract infection, including pharyngitis and rhinitis.
Skin and accessory system: Common: Skin abnormalities such as eczema.
Additionally, since Telmisartan entered the market, there have been individual cases of erythema, itching, syncope, insomnia, depression, stomach discomfort, vomiting, hypotension, bradycardia, tachycardia, dyspnea, eosinophilia, thrombocytopenia, weakness, and reduced work efficiency. Similar to other angiotensin II receptor blockers, very few cases have reported vascular edema, nettles, and other negative reactions.
The laboratory found: compared to the placebo, the Telmisartan group occasionally exhibited lowered hemoglobin or raised uric acid. Any increase in serum creatinine or liver enzymes in the Telmisartan group was similar or lower than that of the placebo group.
PatentTelmisartan was originally formulated by the German pharmaceutical company Boehringer Ingelheim; it earned the German patent EP502,314 in 1991, was first approved to enter the American market in November 1998, and then entered German, Philippines, Australian, Belgium, British, and other markets.
DescriptionTelmisartan was launched in the US for the treatment of hypertension. It can be prepared in eight steps starting with methyl 4-amino-3-methyl benzoate; the first and second cyclization into a benzimidazole ring occur at steps 4 and 6 respectively. Telmisartan blocks the action of angiotensin II (Ang II), the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It is the sixth of this class of 《sartans》 to be marketed after the lead compound Losartan. Its long lasting effect (24h half-life) could be the main difference with other angiotensin II antagonists. Unlike several other agents in this category, its activity does not depend upon transformation into an active metabolite, the 1-O-acylglucuronide being the principal metabolite found in humans. Telmisartan is a potent competitive antagonist of AT1 receptors that mediate most of the important effects of angiotensin II while lacking affinity for the AT2 subtypes or other receptors involved in cardiovascular regulation. In several clinical studies, Telmisartan, at a once daily dosage, produced effective and sustained blood-pressure lowering effects with a low incidence of side effects (particularly treatment-related cough associated with ACE inhibitors in elderly patients).
Chemical PropertiesWhite or off white crystalline powder
OriginatorBoehringer Ingelheim (Germany)
Usescardiotonic
UsesTelmisartan is an angiotensin II receptor antagonist.
Usesanti-cancer agent
UsesUsed alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart
DefinitionChEBI: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Brand nameMicardis (Boehringer Ingelheim).
General DescriptionTelmisartan, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid (Micardis), does not appear to bear any structuralrelationship to this class, but there is actually a great dealof overlap in the chemical architecture with other agents. Thefirst, and most significant, difference is the replacement of theacidic tetrazole system with a simple carboxylic acid. Thisacid, like the tetrazole, plays a role in receptor binding. Thesecond difference is the lack of a carboxylic acid near the imidazolenitrogen that also contributes to receptor binding.As with irbesartan, however, there is not a need for this groupto be acidic but, rather, to be one that participates in receptorbinding. The second imidazole ring, much like a purine basein deoxyribonucleic acid (DNA), can hydrogen bond with theangiotensin II receptor.
Telmisartan Preparation Products And Raw materials
Raw materialsN-Methyl-1,2-benzenediamine dihydrochloride
Tag:Telmisartan(144701-48-4) Related Product Information
Valsartan Telmisartan sodium Telmisartan-d3 Acyl--D-glucuronide 4-Methyl Biphenyl-2-Carboxylate [Telmisartan Intermediates] Telmisartan acyl glucuronide 4-butanamide-3-methyl-5-nitrobenzene carboxylate acid cas:(intermediate of telmisartan) 3-methyl-4-n-butyramide-5-amino-benzoic acid methyl ester (intermediate of telmisartan) Telmisartan Methyl Ester TERT-BUTHYL 4'-(METHYL)BIPHENYL-2-CARBOXYLATE(FOR TELMISARTAN) N-METHYL-O-PHENLENEDIAMINE DIHYDROCHLORIDE/INTERMEDIATE OF TELMISARTAN METHYL4/-(BROMOMETHYL)-BIPHENYL2-CARBOXLATE/INTERMEDIATE OF TELMISARTAN Intermediate of Telmisartan A 2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOLE-2-YL)BENZIMIDAZOLE(INTERMEDIATE OF TELMISARTAN) 2-N-PROPY1-4-METHYL-6-(1-METHYL BENZIMIDAZOLE-2-YL) BENZIMIDAZOLE/INTERMEDIATE OF TELMISARTAN TELMISARTAN-D3 ACYL-B-D-GLUCURONIDE TELMISARTAN SODIUM 4'-[[1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl]-methyl]-1,1'-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester METHYL 4'-[[2-N-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOL-2-YL)-BENZIMIDAZOL-1-YL]METHYL]BIPHENYL-2-CARBOXYLATE