| Company Name: |
Chengdu RunZeBenTu Chemical Co., Ltd
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| Tel: |
13096311329 028-88469284 616445927 |
| Email: |
616445927@qq.com |
| Products Intro: |
Product Name:NA
CAS:959417-21-1
Package:5g/25g/100g/250g/500g
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| Company Name: |
Lynnchem
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| Tel: |
86-(0)29-85992781 17792393971 |
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info@lynnchem.com |
| Products Intro: |
Product Name:4-Hydroxyalternariol
CAS:959417-21-1
Purity:>95% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:4-Hydroxyalternariol
CAS:959417-21-1
Purity:>95% by HPLC Package:1mg;5mg
|
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| | 4-Hydroxyalternariol Basic information |
| Product Name: | 4-Hydroxyalternariol | | Synonyms: | 4-Hydroxyalternariol;Hydroxyalternariol, 4-;3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-;Alternariol Impurity 18;3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one | | CAS: | 959417-21-1 | | MF: | C14H10O6 | | MW: | 274.23 | | EINECS: | | | Product Categories: | | | Mol File: | 959417-21-1.mol |  |
| | 4-Hydroxyalternariol Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid |
| | 4-Hydroxyalternariol Usage And Synthesis |
| Description | 4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions. | | Uses | 4-Hydroxy Alternariol is a derivative of Alternariol (A575760). Alternariol is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. | | Uses | 4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date. |
| | 4-Hydroxyalternariol Preparation Products And Raw materials |
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