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BIONNA MEDICINE CO.,LTD |
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Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide CAS:1335210-35-9 Purity:0.99 Package:500g;1kg
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Capot Chemical Co.,Ltd. |
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571-85586718 +8613336195806 |
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Product Name:(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide CAS:1335210-35-9 Purity:NLT 98% Package:1G;1KG;100KG
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Company Name: |
Hangzhou FandaChem Co.,Ltd. |
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008657128800458; +8615858145714 |
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fandachem@gmail.com |
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Product Name:(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide CAS:1335210-35-9 Purity:as in COA Package:as customers' requirements
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Shanghai Yingrui Biopharma Co., Ltd. |
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+86-21-33585366 - 03@ |
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sales03@shyrchem.com |
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Product Name:(4R,12aS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide CAS:1335210-35-9 Purity:99% Package:0KG;0USD
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- (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide
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- $1.00 / 1g
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2021-01-06
- CAS:1335210-35-9
- Min. Order: 1g
- Purity: 85.0-99.8%
- Supply Ability: 20tons
- (4R,12aS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxamide
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- $1.00 / 1KG
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2018-03-07
- CAS:1335210-35-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100t
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| O-Methyl Dolutegravir Basic information |
Product Name: | O-Methyl Dolutegravir | Synonyms: | (4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;(4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-car boxamide;Dolutegravir O-Methyl Imp;Dolutegravir impurity 5/O-Methyl Dolutegravir/(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-, (4R,12aS)-;O-Methyl Dolutegravir;BNKY001-DL03 | CAS: | 1335210-35-9 | MF: | C21H21F2N3O5 | MW: | 433.41 | EINECS: | | Product Categories: | CMLLYL | Mol File: | 1335210-35-9.mol | |
| O-Methyl Dolutegravir Chemical Properties |
Boiling point | 684.3±55.0 °C(Predicted) | density | 1.45±0.1 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | pka | 10.70±0.40(Predicted) |
| O-Methyl Dolutegravir Usage And Synthesis |
Description | Dolutegravir intermediate is a new synthetic intermediate of Dolutegravir. Dolutegravir is an integrase inhibitor used to treat human immunodeficiency virus (HIV)-1 infection. | Uses | (4R,12AS)-N-(2,4-Difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1'',2'':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide is an intermediate in the preparation of dolutegravir, an integrase inhibitor for HIV-1 infection therapy. | Synthesis |
(3S,11aR)-3-methyl-6-(methyloxy)-5,7-dioxo-2,3,5,7,11,11a- hexahydro[1,3]oxazolo [3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid (100 gm) and carbonyl dimidazole (78.89 gm) was suspended in acetonitrile (1000 mL). The mixture was heated to 75°C and stirred for 1 hour. The resulting solution was cooled to a temperature of 20°C and treated with 2,4- difluorobenzyl amine solution (55.2 gm was dissolved in 200 mL of acetonitrile). The reaction mixture was maintained for 2 hours, concentrated, and the compound was extracted with ethyl acetate (1000 mL). Isopropyl alcohol (500 mL) was added at 40°C, stirred the reaction mass for 30 minutes at a temperature of 50°C, and cooled the reaction mass to 25°C. The reaction mixture was maintained for 8 hours at the same temperature. The product O-Methyl Dolutegravir was collected by filtration and dried under vacuum (85 gm).
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| O-Methyl Dolutegravir Preparation Products And Raw materials |
Raw materials | (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid-->2,4-Difluorobenzylamine | Preparation Products | Dolutegravir sodium |
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