| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:5MPN
CAS:47208-82-2
Purity:98.92% Package:2mg/RMB 987;50mg/RMB 9320;25mg/RMB 7170
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:5MPN
CAS:47208-82-2
Purity:95.00% Package:2mg;25mg;50mg
|
| Company Name: |
https://hanhongsci.com/
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| Tel: |
021-54306202 18917919676 |
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info@hanhongsci.com |
| Products Intro: |
Product Name:5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE
CAS:47208-82-2
Purity:98+% Package:5mg;25mg;100mg;1g;5g
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| | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Basic information |
| | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Chemical Properties |
| Boiling point | 493.8±40.0 °C(Predicted) | | density | 1.244±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 6.36±0.50(Predicted) | | form | Solid | | color | White to light yellow |
| | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Usage And Synthesis |
| Uses | 5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines[1]. | | in vivo | 5MPN (120 mg/kg; p.o.) suppresses the growth of Lewis lung carcinomas (LLC) grown in syngeneic mice and H460 human lung adenocarcinoma xenografts grown in athymic mice without affecting body weight[1].
5MPN causes a reduction in Ki67-positive cells in the LLC xenografts suggesting that 5MPN may be reducing cell cycle progression in vivo[1]. | Animal Model: | C57BL/6 mice[1] | | Dosage: | 120 mg/kg | | Administration: | P.o. | | Result: | Suppressed the growth of Lewis lung carcinomas (LLC) grown in syngeneic mice and H460 human lung adenocarcinoma xenografts grown in athymic mice without affecting body weight.
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| | References | [1] Chesney J, et al. Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor. Oncotarget. 2015;6(20):18001-18011. DOI:10.18632/oncotarget.4534 |
| | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Preparation Products And Raw materials |
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