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Chenodeoxycholic acid

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Company Name: Jiangsu Zhongbang Pharmaceutical Co., Ltd.
Tel: 025-87151996
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Products Intro: Product Name:CDCA
CAS:474-25-9
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
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Products Intro: Product Name:Chenodeoxycholic acid
CAS:474-25-9
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Shanghai Zheyan Biotech Co., Ltd.
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Products Intro: Product Name:Chenodeoxycholic acid
CAS:474-25-9
Purity:HPLC>=98% Package:20mg
Company Name: Kono Chem Co., Ltd
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Products Intro: Product Name:Chenodeoxycholic acid
CAS:474-25-9
Purity:99% Package:1g;25g;1kg;25kg;100kg Remarks:Pharmaceutical grade
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Chenodeoxycholic acid
CAS:474-25-9
Purity:Not available Package:100g;1kg;5kg,10kg,25kg,50kg

Lastest Price from Chenodeoxycholic acid manufacturers

  • Chenodeoxycholic acid
  • US $7.00 / kg
  • 2018-12-19
  • CAS:474-25-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100KG
  • Chenodeoxycholic acid
  • US $1.00 / KG
  • 2018-09-18
  • CAS:474-25-9
  • Min. Order: 1KG
  • Purity: 99%(Customizable specifications)
  • Supply Ability: 2000kg
Chenodeoxycholic acid Basic information
Product Name:Chenodeoxycholic acid
Synonyms:URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure
CAS:474-25-9
MF:C24H40O4
MW:392.57
EINECS:207-481-8
Product Categories:-;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor
Mol File:474-25-9.mol
Chenodeoxycholic acid Structure
Chenodeoxycholic acid Chemical Properties
Melting point 165-167 °C(lit.)
alpha 12 º (c=1, CHCl3)
Boiling point 437.26°C (rough estimate)
density 0.9985 (rough estimate)
refractive index 1.4460 (estimate)
Fp 9℃
storage temp. Refrigerator
solubility PRACTICALLY INSOLUBLE
form Powder
pkapKa 4.34 (Uncertain)
color White to off-white
Water Solubility PRACTICALLY INSOLUBLE
Merck 13,2062
BRN 3219887
InChIKeyRUDATBOHQWOJDD-BSWAIDMHSA-N
CAS DataBase Reference474-25-9(CAS DataBase Reference)
EPA Substance Registry SystemCholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- (474-25-9)
Safety Information
Hazard Codes Xn
Risk Statements 63
Safety Statements 22-24/25-45-36/37
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 2
RTECS FZ1980000
HS Code 29181990
MSDS Information
ProviderLanguage
3alpha,7alpha-Dihydroxy-5beta-cholanic acid English
SigmaAldrich English
ACROS English
Chenodeoxycholic acid Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesChenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.It is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
  1. Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.
  2. Chenodeoxycholic Acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for Dye Solar Cells. This co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation.
  3. Chenodeoxycholic Acid is a white solid added with the dye powder to the solvent while preparing staining solutions. The concentration of co-adsorbent is typically 10 fold the dye concentration.
  4. Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX).
  5. It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.
  6. Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.EC50 concentrations for activation of FXR range from 13-34 μM.In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.
HistoryChenodeoxycholic acid was isolated in 1924 from goose gall by Adolf Windaus and human gall by Heinrich Wieland.Its complete structural configuation was elucidated by Hans Lettre at the University of Gottingen.
In 1968, William Admirand and Donald Small at Boston University Medical School established that in patients with gallstones their bile was saturated with cholesterol, sometimes even exhibiting microcrystals, whereas this was not the case in normal people.It was then found that biliary levels of cholic acid and chenodeoxycholic acid were lower in patients with cholesterol gallstones than in normal people. Leslie Thistle and John Schoenfield at the Mayo Clinic in Rochester, Minnesota, then administered individual bile salts by mouth for four months and found that chenodeoxycholic acid reduced the amount of cholesterol in the bile.This led to a national collaborative study in the United States, which confirmed the effectiveness of chenodeoxycholic acid in bringing about dissolution of gallstones in selected patients. However, recent developments such as laparoscopic cholecystectomy and endoscopic biliary techniques have curtailed the role of chenodeoxycholic acid and ursodeoxycholic acid in the treatment of cholelithiasis.
Usesanticholithogenic, antilipemic agent
UsesA major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.
UsesAn apoptosis inducer via PKC-dependent signalling pathway.
Purification MethodsThis major bile acid in vertebrates (~80mg) is chromatographed on silica gel (5g) and eluted with CHCl3/EtOAc (3:2) and crystallised from EtOAc/hexane. It has IR: max 1705 cm-1(CHCl3). It also crystallises from EtOAc, EtOAc/heptane after purifying via the poorly soluble Na and K salt if necessary. [Kametani et al. J Org Chem 4 7 2331 1982, Beilstein 10 IV 1604.]
Chenodeoxycholic acid Preparation Products And Raw materials
Preparation ProductsUrsodeoxycholic acid-->squalamine
Raw materialsEtanol-->Sodium carbonate-->Barium chloride-->Hydrochloric acid alcohol-->Sodium cholate
Tag:Chenodeoxycholic acid(474-25-9) Related Product Information
Chenodeoxycholic acid sulfate conjugate CHENODEOXYCHOLIC ACID DIACETATE METHYL ESTER Chenodeoxycholic Acid, Free Acid Chenodeoxycholic acid and its sodium salt CHENODEOXYCHOLIC ACID SODIUM ACETIC ACID Deoxycholic acid Ursodeoxycholic acid Hyodeoxycholic acid Chenodeoxycholic acid 12-HYDROXYSTEARIC ACID Sodium deoxycholate p-Hydroxy-cinnamic acid Citric acid 5Β-CHOLANIC ACID Folic acid Hyaluronic acid Ascoric Acid