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Ibandronate sodium monohydrate

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Company Name: Chengdu Aslee Biopharmaceuticals, Inc.
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Products Intro: Product Name:Ibandronate Sodium
CAS:138926-19-9
Purity:99% Package:1KG;USD
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Products Intro: Product Name:[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt
CAS:138926-19-9
Purity:99% Package:100g ;1KG ;5KG 25KG
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Products Intro: Product Name:Ibandronate Sodium
CAS:138926-19-9
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
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Products Intro: Product Name:Ibandronate sodium monohydrate
CAS:138926-19-9
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
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Products Intro: Product Name:Ibandronate sodium monohydrate
CAS:138926-19-9
Purity:98% Package:1KG;15USD

Ibandronate sodium monohydrate manufacturers

  • Ibandronate sodium
  • Ibandronate sodium pictures
  • $15.00 / 1KG
  • 2021-07-02
  • CAS:138926-19-9
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Ibandronate Sodium
  • Ibandronate Sodium   pictures
  • $1.00 / 1KG
  • 2020-03-16
  • CAS:138926-19-9
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20 tons
Ibandronate sodium monohydrate Basic information
Product Name:Ibandronate sodium monohydrate
Synonyms:Ibandrate;Ibandromate Monosodium; Sodium Trihydrogen (1-Hydroxy-3-(methylpenthylamino)propylidene)diphosphonate Monohydrate;BM-21.0955;Boniva;Bonviva;IBANDRONATE SODIUM/1-HYDROXY-3-(METHYLPENTYLAMINO)PROPYLIDENE;Ibadronate SodiuM
CAS:138926-19-9
MF:C9H24NNaO8P2
MW:359.23
EINECS:639-757-2
Product Categories:Inhibitors;BONIVA;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Ibandronate;anti-osteoporosis;Bone resorption inhibitor
Mol File:138926-19-9.mol
Ibandronate sodium monohydrate Structure
Ibandronate sodium monohydrate Chemical Properties
Melting point 840C (dec)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form solid
color White
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference138926-19-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 22-36-24/25
HS Code 29319090
MSDS Information
Ibandronate sodium monohydrate Usage And Synthesis
DescriptionIbandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
Ibandronate Sodium Monohydrate inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's. Ibandronate Sodium Monohydrate is an inhibitor of FDPS.
Chemical Properties[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt is White Crystalline Powder
UsesInhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as asteoporosis, metastatic disease, and Paget d
UsesAn inhibitor of bone resorption
Usesbone resorption inhibitor, anthypercalcemic
Mechanism of actionThe action of ibandronate on bone tissue is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
PharmacokineticsAbsorption
The absorption of oral ibandronate occurs in the upper gastrointestinal tract. Plasma concentrations increase in a dose-linear manner up to 50 mg oral intake and increases nonlinearly above this dose.
Following oral dosing, the time to maximum observed plasma ibandronate concentrations ranged from 0.5 to 2 hours (median 1 hour) in fasted healthy postmenopausal women. The mean oral bioavailability of 2.5 mg ibandronate was about 0.6% compared to intravenous dosing. The extent of absorption is impaired by food or beverages (other than plain water). The oral bioavailability of ibandronate is reduced by about 90% when BONIVA is administered concomitantly with a standard breakfast in comparison with bioavailability observed in fasted subjects. There is no meaningful reduction in bioavailability when ibandronate is taken at least 60 minutes before a meal. However, both bioavailability and the effect on bone mineral density (BMD) are reduced when food or beverages are taken less than 60 minutes following an ibandronate dose.
Distribution
After absorption, ibandronate either rapidly binds to bone or is excreted into urine. In humans, the apparent terminal volume of distribution is at least 90 L, and the amount of dose removed from the circulation via the bone is estimated to be 40% to 50% of the circulating dose. In vitro protein binding in human serum was 99.5% to 90.9% over an ibandronate concentration range of 2 to 10 ng/mL in one study and approximately 85.7% over a concentration range of 0.5 to 10 ng/mL in another study.
Metabolism
There is no evidence that ibandronate is metabolized in humans.
https://www.accessdata.fda.gov
References1) Russell (2006), Ibandronate: Pharmacology and preclinical studies; Bone 38 S7
Ibandronate sodium monohydrate Preparation Products And Raw materials
Raw materialsIbandronic acid
Tag:Ibandronate sodium monohydrate(138926-19-9) Related Product Information
Pamidronic acid Ibandronate Sodium Anhydrous Olpadronate Sodium b-Alanine, N-methyl-N-pentyl- Ibandronate Impurity 1(Ibandronate EP Impurity B) Alendronate sodium Letrozole 3,5-Bis(2-cyanoprop-2-yl)toluene INTERMEDIATE OF IBANDRONATE SODIUM N-Pentyl-β-alanine ETHYLENEDIAMINETETRAACETIC ACID TRIPOTASSIUM SALT DIHYDRATE Disodium edetate dihydrate N-DesMethyl Ibandronate SodiuM methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate Tetramethyl Ibandronate Trisodium phosphate Acryloyl chloride N-Methylpentylamine