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STACHYDRINE HYDROCHLORIDE

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Products Intro: Product Name:STACHYDRINE HYDROCHLORIDE
CAS:4136-37-2
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Products Intro: Product Name:Stachydrine hydrochloride
CAS:4136-37-2
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CAS:4136-37-2
Purity:99% Package:25kg
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CAS:4136-37-2
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Products Intro: Product Name:Stachydrine hydrochlori
CAS:4136-37-2
Purity:HPLC>=98% Package:20mg

STACHYDRINE HYDROCHLORIDE manufacturers

STACHYDRINE HYDROCHLORIDE Basic information
Product Name:STACHYDRINE HYDROCHLORIDE
Synonyms:STACHYDRINE HYDROCHLORIDE;(S)-2-carboxy-1,1-dimethylpyrrolidinium chloride;StachydrineHCl;Stachydrine hydrichloride;2-Carboxy-1,1-dimethylpyrrolidinium chloride;Stachydrine chloride;Stachydrine hydrochlori;Stachydrine chloride 2-Carboxy-1,1-dimethylpyrrolidinium chloride
CAS:4136-37-2
MF:C7H14ClNO2
MW:179.64
EINECS:223-957-8
Product Categories:Ammonium Chlorides (Quaternary);Quaternary Ammonium Compounds
Mol File:4136-37-2.mol
STACHYDRINE HYDROCHLORIDE Structure
STACHYDRINE HYDROCHLORIDE Chemical Properties
Melting point 225°C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
color White to Off-White
Water Solubility Soluble in water
Merck 14,8771
Stability:Hygroscopic
CAS DataBase Reference4136-37-2(CAS DataBase Reference)
Safety Information
Risk Statements 20-22
Safety Statements 22-45-36/37/39
HS Code 29339900
MSDS Information
STACHYDRINE HYDROCHLORIDE Usage And Synthesis
UsesStachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis.
Biological Activitystachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits.
in vitrothe aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1].
in vivoprevious study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].
targetIL Receptor | T-bet | RORγt | GATA-3 | Foxp3
references[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).
[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54.
STACHYDRINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materialsL-Proline-->Iodomethane
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