EMD 270179 manufacturers
- EMD 270179
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- $28.00 / 1box
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2024-06-05
- CAS:197172-76-2
- Min. Order: 1box
- Purity: 99%
- Supply Ability: 20000
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| | EMD 270179 Basic information |
| Product Name: | EMD 270179 | | Synonyms: | Cyclo(1-aminocyclohexanecarbonyl-L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl);Cyclopeptide-5;EMD 270179;RonaCare Cyclopeptide 5;Cyclotetrapeptide-24 aminocyclohexane carboxylate;Cyclopeptide-5/CycloTetrapeptide-24 AminocyclohexaneCarboxylate;Cyclo(1-aminocyclohexanecarbonyl-L-arginylglycyl-L-α-aspartyl-D-phenylalanyl);2-((9R,12S,18S)-9-Benzyl-18-(3-guanidinopropyl)-8,11,14,17,20-pentaoxo-7,10,13,16,19-pentaazaspiro[5.14]icosan-12-yl)acetic acid | | CAS: | 197172-76-2 | | MF: | C28H40N8O7 | | MW: | 600.67 | | EINECS: | | | Product Categories: | | | Mol File: | 197172-76-2.mol |  |
| | EMD 270179 Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | pka | 4.00±0.10(Predicted) |
| | EMD 270179 Usage And Synthesis |
| Uses | Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2]. | | References | [1] M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26(3):283-9. DOI:10.1007/s00726-003-0042-8
[2] Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1038-45. DOI:10.1152/ajpheart.01054.2006 |
| | EMD 270179 Preparation Products And Raw materials |
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