- 2-Thiophenesulfonamide
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- $1.00 / 1KG
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2020-02-04
- CAS:6339-87-3
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | Thiophene-2-sulfonamide Basic information |
| | Thiophene-2-sulfonamide Chemical Properties |
| Melting point | 137-141 °C | | Boiling point | 338.1±34.0 °C(Predicted) | | density | 1.513±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 9.94±0.60(Predicted) | | color | White to Light yellow to Light orange | | InChI | 1S/C4H5NO2S2/c5-9(6,7)4-2-1-3-8-4/h1-3H,(H2,5,6,7) | | InChIKey | KTFDYVNEGTXQCV-UHFFFAOYSA-N | | SMILES | NS(=O)(=O)c1cccs1 | | CAS DataBase Reference | 6339-87-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | RTECS | XN0294000 | | HS Code | 29350090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Thiophene-2-sulfonamide Usage And Synthesis |
| Definition | ChEBI: 2-Thiophenesulfonamide is a member of thiophenes. | | Synthesis Reference(s) | Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6 | | Synthesis | General procedure for the synthesis of 2-thiophenesulfonamide from 2-thiophenesulfonyl chloride:
Example: preparation of 2-thiophenesulfonamide
2-Thiophenesulfonyl chloride (0.5 g, 2.74 mmol) was added to 25% ammonium hydroxide solution (5 mL, 33.45 mmol), refluxed and stirred at 50°C for 15 hours. Upon completion of the reaction, the reaction mixture was filtered while hot and the residue was washed with boiling aqueous 25% ammonium hydroxide solution. Subsequently, the ammonium hydroxide solution was removed by vacuum distillation until there was no ammonia odor. Eventually, 2-thiophenesulfonamide was recrystallized from water to give a white solid (0.328 g, 77% yield).
Product Characterization:
Melting point: 145-146°C;
IR spectrum (KBr, cm?1): 3290 (N-H stretching vibration), 3224 (N-H stretching vibration);
NMR hydrogen spectrum (400 MHz, DMSO-d6, δ): 7.15 (1H, dd, J = 5.0, 3.7 Hz, C(4)H), 7.55 (1H, dd, J = 3.7, 1.4 Hz, C(3)H), 7.66 (2H, s, NH2), 7.85 (1H, dd, J = 5.0, 1.4 Hz, C(5)H);
NMR carbon spectrum (100 MHz, DMSO-d6, δ): 127.3, 130.0, 131.1, 145.7;
Mass spectrum (ESI?): m/z 162 ([M-H]? , 100%);
High-resolution mass spectrum (ESI?): C4H4NO2S2 ([M-H]?) Calculated value 161.9689, measured value 161.9695. | | References | [1] Journal of the American Chemical Society, 2010, vol. 132, # 10, p. 3238 - 3239
[2] Patent: WO2011/55142, 2011, A2. Location in patent: Page/Page column 47
[3] Phosphorus and Sulfur and the Related Elements, 1981, vol. 10, p. 111 - 120
[4] Phosphorus and Sulfur and the Related Elements, 1980, vol. 8, p. 197 - 200
[5] Justus Liebigs Annalen der Chemie, 1933, vol. 501, p. 174,182 |
| | Thiophene-2-sulfonamide Preparation Products And Raw materials |
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