- Ethyl 2-chloronicotinate
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- $100.00 / 1kg
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2024-04-22
- CAS:1452-94-4
- Min. Order: 1kg
- Purity: 99.93%
- Supply Ability: 1000kg per week
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| | Ethyl 2-chloronicotinate Basic information |
| | Ethyl 2-chloronicotinate Chemical Properties |
| Melting point | 68 C | | Boiling point | 78°C (0.1 mmHg) | | density | 1.2445 g/cm3(Temp: 25 °C) | | refractive index | 1.5210-1.5250 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | -1.32±0.10(Predicted) | | color | Colorless to Light yellow to Light orange | | InChI | InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3 | | InChIKey | PMIMPBYTPPRBGD-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC=C1C(OCC)=O | | CAS DataBase Reference | 1452-94-4(CAS DataBase Reference) |
| Provider | Language |
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ALFA
| English |
| | Ethyl 2-chloronicotinate Usage And Synthesis |
| Chemical Properties | Light yellow liquid | | Uses | Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate. | | Synthesis Reference(s) | Tetrahedron, 51, p. 13177, 1995 DOI: 10.1016/0040-4020(95)00788-A | | Synthesis | 2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil. |
| | Ethyl 2-chloronicotinate Preparation Products And Raw materials |
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