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| | SirReal2 Basic information |
| Product Name: | SirReal2 | | Synonyms: | SirReal2;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide | | CAS: | 709002-46-0 | | MF: | C22H20N4OS2 | | MW: | 420.55 | | EINECS: | | | Product Categories: | | | Mol File: | 709002-46-0.mol |  |
| | SirReal2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml | | form | A crystalline solid |
| | SirReal2 Usage And Synthesis |
| Description | Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation. | | Uses | SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor. | | storage | Store at -20°C |
| | SirReal2 Preparation Products And Raw materials |
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