Log in | Join Free | china | japan | germany

Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)

Request For Quotation
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Suppliers list
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)
Purity:Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Package:50MG Remarks:803243-50MG
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Basic information
Product Name:Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)
Synonyms:Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Structure
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Chemical Properties
storage temp. -20°C
form powder
Safety Information
MSDS Information
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Usage And Synthesis
General DescriptionSMPB and its water-soluble analog Sulfo-SMPB are heterobifunctional crosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these crosslinkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Preparation Products And Raw materials
Tag:Sulfo-SMPB (sulfosuccinimidyl 4-(N-maleimidophenyl)butyrate) Related Product Information