| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CAY10703
CAS:1841421-67-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10703
CAS:1841421-67-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10703;CAY10703,CAY-10703
CAS:1841421-67-7
Purity:98% Package:50 mg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10703
CAS:1841421-67-7
Purity:95% Package:1mg;5mg;10mg
|
|
| | CAY10703 Basic information |
| Product Name: | CAY10703 | | Synonyms: | CAY10703;CAY10703,CAY-10703;Acetamide, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[2,2-dichloro-;N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(2,2-dichloroacetamide) | | CAS: | 1841421-67-7 | | MF: | C12H18Cl6N4O3 | | MW: | 479.01 | | EINECS: | | | Product Categories: | | | Mol File: | 1841421-67-7.mol |  |
| | CAY10703 Chemical Properties |
| Boiling point | 680.0±55.0 °C(Predicted) | | density | 1.491±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | | form | A crystalline solid | | pka | 11.84±0.46(Predicted) |
| | CAY10703 Usage And Synthesis |
| Description | Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.1,2 Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.2,3 CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.4 It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.4 It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.4 | | References | 1. Whitehouse, S., Cooper, R.H., and Randle, P.J. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids Biochem. J. 141(3),761-774(1974).
2. Rodrigues, A.S., Correia, M., Gomes, A., et al. Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency PLoS One 10(7),July 2015(2015).
3. Ruggieri, V., Agriesti, F., Scrima, R., et al. Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: A metabolic perspective of treatment Oncotarget 6(2),1217-1230(2015).
4. Trapella, C., Voltan, R., Melloni, E., et al. Design, synthesis, and biological characterization of novel mitochondria targeted dichloroacetate-loaded compounds with antileukemic activity J. Med. Chem. 59(1),147-156(2016). |
| | CAY10703 Preparation Products And Raw materials |
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