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A23187

A23187 Suppliers list
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Calcimycin
CAS:52665-69-7
Purity:>99%
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:52665-69-7
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: Target Molecule Corp
Tel: 781-999-5354
Email: marketing@targetmol.com
Products Intro: Product Name:Calcimycin;A-23187;Antibiotic A-23187;Antibiotic A-23187
CAS:52665-69-7
Purity:98.00% Package:1 mg;5 mg;1 mL * 10 mM (in DMSO) Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Amadis Chemical Company Limited
Tel: 0086-571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:Calcium Ionophore A23187
CAS:52665-69-7
Purity:0.97 Package:mgs,gs,kgs Remarks:A829191
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833- ;010-82848833-
Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:Calcium ionophore A23187, 98%, from Streptomyces chartreusis
CAS:52665-69-7
Purity:98% Package:5MG
A23187 Basic information
Product Name:A23187
Synonyms:A23187 (CalciMycin);CALCIUM IONOPHORE III;CALCIUM IONOPHORE A23187;CALCIMYCIN;CALCIMYCIN A23187;IONOPHORE A-23187;5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid;Bis[5-methylamino-2-[[(6S)-3β,9α,11β-trimethyl-8α-[(S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2β-yl]methyl]-4-benzoxazolecarboxylic acid]calcium salt
CAS:52665-69-7
MF:C29H37N3O6
MW:523.62
EINECS:258-084-1
Product Categories:Signalling;antibiotic;Calcium channel
Mol File:52665-69-7.mol
A23187 Structure
A23187 Chemical Properties
Melting point 187-190 °C
alpha D25 -56° (c = 1 in chloroform)
Boiling point 710.3±55.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
form Solid
pkapKa1 6.9 in 90% DMSO
color white to light yellow
Merck 13,1639
BRN 1096801
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 26-36
WGK Germany 3
RTECS DM4676000
8
HS Code 29349990
ToxicityLD50 i.p. in mice: 10 mg/kg (Gale)
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
A23187 Usage And Synthesis
Chemical Propertieswhite to off-white solid
UsesCalcimycin is a potent calcium ionophore isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium-regulated cellular events.
Biological ActivityCalcium ionophore that induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo .
Purification MethodsIt recrystallises from Me2CO as colourless needles. Protect it from light and moisture, store in a refrigerator. It is soluble in Me2SO or EtOH and can be stored for 3 months without loss of activity. The Mg and Ca salts are soluble in organic solvents and cross biological membranes. It has a pKa of 6.9 in 90% Me2SO. The Ca complex crystallises from 50% EtOH as colourless prisms. It is highly TOXIC. [Pressman Ann Rev Biochem 45 501 1976, Chaney et al. J Am Chem Soc 96 1932 1974, Chaney et al. J Antibiotics 29 124 1976, Suzuki et al. Anal Biochem 61 382 1989, Simon & Carafoli Methods Enzymol 56 439 1977.]
A23187 Preparation Products And Raw materials
Tag:A23187(52665-69-7) Related Product Information
CALCIUM IONOPHORE A23187 MIXEDCALCIUM-MA GNESIUM A-23187, 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER,DMNPE-CAGED A-23187 CALCIUM IONOPHORE A23187 MIXED CALCIUM-& Calcium ionophore A23187(free acid) 50 MG CALCIUM IONOPHOR A 23187RESEARCH GRADE DMNPE-CAGED BR A-23187,4-BROMO A-23187, 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER 4-ISOBUTOXY-2-BUTANONE 2-ETHYL-1,3-BENZOXAZOL-5-AMINE 2-PROPIONYLPYRROLE CALCIMYCIN A23187 HEMICALCIUM SALT,CALCIUM IONOPHORE A23187 HEMICALCIUM SALT,A23187 HEMICALCIUM SALT,calcium ionophore A23187 hemicalcium,CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA,A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt 4-BROMO-ANTIBIOTIC A23187,4-BROMO-CALCIUM IONOPHORE A23187,4-BROMOCALCIMYCIN A23187,4-BR-A23187,4-BROMO-A23187,A23187, 4-BROMO,ANTIBIOTIC A-23187, 4-BROMO,4-Bromo-A23187, 4-Bromo-calcimycin,4-BROMO-CALCIUM IONOPHORE A23187FREE ACI D 2-BUTYL-1,3-BENZOXAZOL-5-AMINE A23187 1,1-DI(2-METHYLBUTOXY)ETHANE 1,1-DI-ISOBUTOXYPROPANE 2-METHYL-1,3-BENZOXAZOL-5-AMINE 5-AMINOBENZOOXAZOLE CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA,calcium ionophore A23187 hemimagnesium,a23187hemimagnesium salt,CALCIMYCIN A23187 HEMIMAGNESIUM SALT,CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT