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6-Gingerol

6-Gingerol Suppliers list
Company Name: Changsha Staherb Natural Ingredients Co., Ltd.
Tel: +86-0731-84213302 +86-18374838656
Email: info@staherb.cn
Products Intro: Product Name:gingerol
CAS:23513-14-6
Purity:>=98% HPLC Package:1KG;USD
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +8618080483897
Email: sales@biopurify.com
Products Intro: Product Name:6-Gingerol
CAS:23513-14-6
Purity:>95%,98%,99% Package:From mgs to grams,up to Kgs Remarks:Can be customized in bulk scale
Company Name: Shaanxi TNJONE Pharmaceutical Co., Ltd
Tel: +8618740459177
Email: sarah@tnjone.com
Products Intro: Product Name:Green Tea Extract Catechin
CAS:23513-14-6
Purity:99% Package:1kg
Company Name: Hebei Zhuanglai Chemical Trading Co.,Ltd
Tel: +8613343047651
Email: admin@zlchemi.com
Products Intro: Product Name:6-Gingerol
CAS:23513-14-6
Purity:99% Package:1kg;120USD
Company Name: Hebei Shengyang Water Conservancy Engineering Co., Ltd.
Tel: +8615373025980
Email: clara@hbshengyang.com
Products Intro: Product Name:6-Gingerol
CAS:23513-14-6
Purity:99.9 Package:10kg;18USD|10kg;18USD|10kg;18USD

6-Gingerol manufacturers

  • gingerol
  • gingerol pictures
  • $0.00 / 1kg
  • 2024-09-19
  • CAS:23513-14-6
  • Min. Order: 1kg
  • Purity: 1-40%
  • Supply Ability: 1000kg
  • 6-Gingerol
  • 6-Gingerol pictures
  • $0.00 / 1KG
  • 2024-09-19
  • CAS:23513-14-6
  • Min. Order: 1KG
  • Purity: ≥98% HPLC
  • Supply Ability: 1000KG
  • 6-Gingerol
  • 6-Gingerol pictures
  • $5.30/ kg
  • 2024-09-13
  • CAS:23513-14-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10 tons
6-Gingerol Basic information
Product Name:6-Gingerol
Synonyms:(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone;(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one;(S)-8-Oxo-10-(3-methoxy-4-hydroxyphenyl)decane-6-ol;6-Gingerol ,98%;3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone;(5S)-[6]-Gingerol;1-(4'-HYDROXY-3'-METHOXYPHENYL)-5-HYDROXY-3-DECANONE;6-GINGEROL
CAS:23513-14-6
MF:C17H26O4
MW:294.39
EINECS:607-241-6
Product Categories:reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Aromatic Phenols;Natural Plant Extract;The group of Ginerols;chemical reagent;pharmaceutical intermediate;phytochemical;Elisa Kit-plant ELISA Kit;23513-14-6
Mol File:23513-14-6.mol
6-Gingerol Structure
6-Gingerol Chemical Properties
Melting point 31℃
Boiling point 453.0±35.0 °C(Predicted)
density 1.083±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility methanol: soluble1mg/mL, clear, colorless
form Pale yellow oil
pka10.02±0.20(Predicted)
color White to Light yellow
InChIInChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
InChIKeyNLDDIKRKFXEWBK-AWEZNQCLSA-N
SMILESC(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC
LogP2.485 (est)
CAS DataBase Reference23513-14-6(CAS DataBase Reference)
NIST Chemistry ReferenceGingerol(23513-14-6)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36/37
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
RTECS HE0757000
HS Code 29145090
MSDS Information
ProviderLanguage
6-Gingerol English
6-Gingerol Usage And Synthesis
Chemical PropertiesLight yellow ceraceous solid
Uses[6]-Gingerol has been used:
  • to study its effects on transient receptor potential (TRP) channels
  • to study its effects on experimental models of non-alcoholic steatohepatitis
  • to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
  • to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice
DefinitionChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
General Description6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.
Biological Activity6-Gingerol is the major pharmacologically-active component of ginger. It is known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. 6-Gingerol has been found to possess anticancer activities via its effect on a variety of biological pathways involved in apoptosis, cell cycle regulation, cytotoxic activity, and inhibition of angiogenesis.
Biochem/physiol ActionsBioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.
Mechanism of action 6-Gingerol suppressed UVB-induced translocation of NF-κB from cytosol to nucleus via prevention of IκBα phosphorylation and COX-2 expression and transactivation in HaCaT cells in vitro. [6]-Gingerol suppressed COX-2 expression at mRNA and protein levels and translocation of NF-κB in UVB-irradiated skin of hairless mice. It suppressed TPA-induced COX-2 gene expression in the skin of mice by inhibiting the p38 MAP kinase-NF-κB signalling pathway. These findings suggest the chemopreventive effect of 6-Gingerol on UVB-induced skin disorders, including cancer. Jeong et al. found that 6-Gingerol inhibited the growth of colon cancer by inhibiting LTA4 hydrolase. 6-Gingerol suppressed PGE2 levels in IL-1β-stimulated human oral keratinocytes. Overall, these studies demonstrated that [6]-gingerol exerts anti-cancer and cancer-preventive activities by targeting the AA pathway.
Anticancer Research 6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, which shows antioxidant, anti-inflammation, and antitumor properties. It has been reported to possess anti-cancer and chemopreventive potentials against several cancers, including skin, colorectal, gastrointestinal and pancreatic. It can inhibit NOS, TNF-α, and COX-2 enzymes, which are regulated by NF-κB. It hinders the cell growth of prostate, gastric, and breast cancer cells and suppresses the lung metastasis of B16F10 melanoma. It exhibits an antitumorigenic effect in human colorectal cancer cells via upregulating NSAID-activated gene-1 (NAG-1). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner. ROS levels were significantly increased in K562 and MOLT4 cells treated with gingerol, and apoptosis was induced in leukaemia cells by the mitochondrial pathway.
6-Gingerol Preparation Products And Raw materials
Tag:6-Gingerol(23513-14-6) Related Product Information
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