| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:IWP-051;IWP 051
CAS:1354041-91-0
Purity:98% Package:5 mg
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| | IWP-051 Basic information |
| Product Name: | IWP-051 | | Synonyms: | IWP-051;4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]- | | CAS: | 1354041-91-0 | | MF: | C17H11F2N5O2 | | MW: | 355.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1354041-91-0.mol |  |
| | IWP-051 Chemical Properties |
| density | 1.53±0.1 g/cm3(Predicted) | | pka | 5.03±0.50(Predicted) |
| | IWP-051 Usage And Synthesis |
| Description | IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans. |
| | IWP-051 Preparation Products And Raw materials |
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