| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CCT241161
CAS:1163719-91-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CCT241161;CCT241161
CAS:1163719-91-2
Purity:98.48% Package:100 mg;5 mg;50 mg
|
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| | CCT241161 Basic information |
| Product Name: | CCT241161 | | Synonyms: | CCT241161;Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-(methylthio)phenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-;N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-(methylthio)phenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-urea;1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-[2-methylsulfanyl-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea | | CAS: | 1163719-91-2 | | MF: | C28H27N7O3S | | MW: | 541.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1163719-91-2.mol |  |
| | CCT241161 Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: Soluble | | form | A solid | | pka | 8.47±0.20(Predicted) |
| | CCT241161 Usage And Synthesis |
| Description | CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK?–ERK, in vitro and in vivo. CCT241161 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs. |
| | CCT241161 Preparation Products And Raw materials |
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