tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate

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CAS:133264-58-1
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Products Intro: Product Name:tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
CAS:133264-58-1
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CAS:133264-58-1
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Products Intro: Product Name:tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
CAS:133264-58-1
Purity:99% HPLC Package:可分装
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Basic information
Product Name:tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate
Synonyms:tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate;Chloroacetamido-C4-NHBoc;Carbamic acid, N-[4-[(2-chloroacetyl)amino]butyl]-, 1,1-dimethylethyl ester
CAS:133264-58-1
MF:C11H21ClN2O3
MW:264.75
EINECS:
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Mol File:133264-58-1.mol
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Structure
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Chemical Properties
Safety Information
MSDS Information
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Usage And Synthesis
Biological ActivityChloroacetamido-C4-NHBoc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
tert-Butyl N-[4-(2-chloroacetamido)butyl]carbamate Preparation Products And Raw materials
Raw materialstert-Butyl N-(4-aminobutyl)carbamate-->Chloroacetyl chloride
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