MRT-92

MRT-92 Suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Email:	marketing@targetmol.cn
Products Intro:	Product Name:MRT-92 CAS:1428315-82-5 Package:50mg/RMB 21300

MRT-92 Basic information

Product Name:	MRT-92
Synonyms:	MRT-92;Benzamide, N-[imino[[4-methyl-3-[[4-(2-phenylethyl)benzoyl]amino]phenyl]amino]methyl]-3,4,5-trimethoxy-
CAS:	1428315-82-5
MF:	C33H34N4O5
MW:	566.65
EINECS:
Product Categories:
Mol File:	1428315-82-5.mol

MRT-92 Chemical Properties

density	1.20±0.1 g/cm3(Predicted)
pka	10.29±0.46(Predicted)

Safety Information

MSDS Information

MRT-92 Usage And Synthesis

Uses	MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1].
References	[1] Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015): 1817. DOI:10.1096/fj.14-267849

MRT-92 Preparation Products And Raw materials

Tag:MRT-92(1428315-82-5) Related Product Information

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