| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Ki11502
CAS:347155-76-4
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:SML1161
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Ki11502 >=98% (HPLC)
CAS:347155-76-4
Purity:NULL Package:25mg;5mg Remarks:NULL
|
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| | PDGFR Tyrosine Kinase Inhibitor V Basic information |
| | PDGFR Tyrosine Kinase Inhibitor V Chemical Properties |
| density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 8.69±0.70(Predicted) | | form | powder | | color | white to brown |
| | PDGFR Tyrosine Kinase Inhibitor V Usage And Synthesis |
| Definition | ChEBI: Ki11502 is a member of the class of quinolines that acts as a receptor tyrosine kinase inhibitor and apoptosis inducer with potential for use in treatment of leukemia and colorectal cancer. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a member of quinolines, a member of thioureas, an aromatic ether and a member of benzamides. | | General Description | A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.). | | Biochem/physiol Actions | Cell permeable: yes |
| | PDGFR Tyrosine Kinase Inhibitor V Preparation Products And Raw materials |
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