S 3304
| 中文名称 | S 3304 |
|---|---|
| 中文同义词 | (R)-3-(1H-吲哚-3-基)-2-(5-(对甲苯基炔基)噻吩-2-亚磺酰氨基)丙酸;化合物S 3304 |
| 英文名称 | (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid |
| 英文同义词 | (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid;R-3-(1H-Indol-3-yl)-2-(5-(p-tolyleth ynyl)thiophene-2;(2R)-3-(1H-indol-3-yl)-2-{5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamido}propanoic acid;(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid;D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-;(R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid;S 3304,Inhibitor,inhibit,S3304,MMP,S-3304,Matrix metalloproteinases |
| CAS号 | 203640-27-1 |
| 分子式 | C24H20N2O4S2 |
| 分子量 | 464.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 203640-27-1.mol |
| 结构式 |  |
S 3304 性质
| 沸点 | 745.7±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 碱性溶液（微溶），DMSO（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.29±0.10(Predicted) |
| 颜色 | 淡米色至浅米色 |
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MMP-9
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S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors.
In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen.