| Company Name: |
Xi'an Confluore Biological Technology Co., Ltd.
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| Tel: |
+86-156-80926068 +86-15680926068 |
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1924344760@qq.com |
| Products Intro: |
Product Name:N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester CAS:2093152-78-2 Purity:95% HPLC Package:10MG;25MG;50MG;100MG;1G;5G
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N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester manufacturers
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| | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Basic information |
| | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Chemical Properties |
| Boiling point | 546.2±50.0 °C(Predicted) | | density | 1.069±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DMF, DCM | | pka | -1.61±0.70(Predicted) |
| | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Usage And Synthesis |
| Description | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry branched linker. The propargyl group can react with azide-bearing compounds through Click Chemistry, the t-butyl protected carboxyl group can also be deprotected under mild acidic conditions. | | Uses | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Preparation Products And Raw materials |
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