- Bakuchiol
-
- $0.00 / 1kg
-
2024-04-29
- CAS:10309-37-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 500
- Bakuchiol
-
- $0.00 / 1g
-
2024-04-28
- CAS:10309-37-2
- Min. Order: 1g
- Purity: ≥98% HPLC
- Supply Ability: 1000kg
- Bakuchiol
-
- $0.00 / 1kg
-
2024-04-26
- CAS:10309-37-2
- Min. Order: 0.10000000149011612kg
- Purity: 99%
- Supply Ability: 2000kg
Related articles - Anti-aging effects of Bakuchiol
- Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with prom....
- Dec 26，2023
|
| | Bakuchiol Basic information |
| Product Name: | Bakuchiol | | Synonyms: | P-(3,7-DIMETHYL-3-VINYLOCTA-TRANS-1,6-DIMETHYL) PHENOL;7-dimethyl-1,6-octadienyl)-4-(3-ethenyl-(s-(e))-pheno;BACTRIS GASIPAES FRUIT JUICE;(S)-Bakuchiol;4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadienyl]phenol;4-[(1E,3S)-3-Vinyl-3,7-dimethyl-1,6-octadienyl]phenol;4-[(S,E)-3-Ethenyl-3,7-dimethyl-1,6-octadienyl]phenol;Aids046581 | | CAS: | 10309-37-2 | | MF: | C18H24O | | MW: | 256.38 | | EINECS: | 685-515-4 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 10309-37-2.mol |  |
| | Bakuchiol Chemical Properties |
| Boiling point | 391℃ | | density | 0.963 | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.4500 (estimate) | | Fp | 177℃ | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml) | | pka | 10.10±0.26(Predicted) | | color | Oil | | optical activity | [α]/D +24.0 to +30.0°, c = 0.1 in chloroform | | BRN | 3611720 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | InChIKey | LFYJSSARVMHQJB-WYMLVPIESA-N | | LogP | 5.09 at 20℃ and pH6.31 | | Surface tension | 43.92mN/m at 1g/L and 20℃ |
| WGK Germany | 3 | | RTECS | SL3785000 | | Toxicity | LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80 |
| | Bakuchiol Usage And Synthesis |
| Description | Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects. | | Uses | (S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol
is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells. | | Safety Profile | Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes. | | Mode of action | The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6]. | | References | 1) Adhikari et al. (2007), Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants; J. Clin. Biochem. Nutr., 40 174
2) Kim et al. (2013), Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage; Toxicol. Appl. Pharmacol., 269 109
3) Zhang et al. (2017), Bakuchiol protects against acute lung injury in septic mice; Inflammation, 40 351
4) Kim et al. (2016), Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia; Molecules, 21 E1076
[5] Zhenlong Xin . “Bakuchiol: A newly discovered warrior against organ damage.” Pharmacological research 141 (2019): Pages 208-213.
[6] Jianyu Feng. “Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.” Apoptosis 71 1 (2016): 532–545. |
| | Bakuchiol Preparation Products And Raw materials |
|