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Carnosic acid

Carnosic acid Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718 +86(0)13336195806
Email: sales@capotchem.com
Products Intro: Product Name:Carnosic acid from Rosmarinus officinalis
CAS:3650-09-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Carnosic acid
CAS:3650-09-7
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:3650-09-7
CAS:3650-09-7
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: Product Name:Carnosic Acid
CAS:3650-09-7
Purity:98% Package:1G;210USD
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Carnosic acid
CAS:3650-09-7
Purity:HPLC>=98% Package:20mg

Carnosic acid manufacturers

  • Carnosic acid
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:3650-09-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Carnosic acid
  • $15.00-10.00 / KG
  • 2021-07-10
  • CAS:3650-09-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Carnosic acid
  • $15.00-10.00 / KG
  • 2021-07-02
  • CAS:3650-09-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Carnosic acid Basic information
Description References
Product Name:Carnosic acid
Synonyms:CARNOSOLIC ACID;CARNOSIC ACID;4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-;(4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid;CARNOSIC ACID(P);CARNOSIC ACID(P)(NOW AVAILABLE IN GRAM SIZES)(P);salvin;(4aR-trans)-1,3,4,9,10,10a-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid
CAS:3650-09-7
MF:C20H28O4
MW:332.43
EINECS:609-253-7
Product Categories:chemical reagent;pharmaceutical intermediate;Plant extracts;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products
Mol File:3650-09-7.mol
Carnosic acid Structure
Carnosic acid Chemical Properties
Melting point 190°C(lit.)
Boiling point 506.4±50.0 °C(Predicted)
density 1.184±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka4.14±0.40(Predicted)
form powder
color yellow
BRN 2707918
InChIKeyQRYRORQUOLYVBU-VBKZILBWSA-N
CAS DataBase Reference3650-09-7(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29182900
MSDS Information
ProviderLanguage
SigmaAldrich English
Carnosic acid Usage And Synthesis
DescriptionCarnosic acid (salvin) is abundant in sage and rosemary leaves. It has antioxidative, anti-carcinogenic, anti-inflammatory, anti-microbial, anti-adipogenic, antiproliferative, antitumorigenic and neuroprotective properties. It is increasingly exploited within food, nutrition health, and cosmetic industries. It is used as the main active antioxidants of food additives in Europe, in products including oils, animal fats, sauces, bakery wares, meat, and fish products etc. to prevent oxidation and prolong their storage time. It is proven to be efficient in the treatment of hyperglycemia. In cosmetic industry, it is used in the hair care and skin care products. Oral health care is another cosmetics-related application of carnosic acid: in vitro studies have shown that it efficiently protected against typical cariogenic microorganisms. It is the important raw material of tooth grinding and gargle agent.
References[1] Simona Birtic, Pierre Dussort, Francois-Xavier Pierre, Antoine C. Bily, Marc Roller (2015) Carnosic acid,115, 9-19
[2] https://en.wikipedia.org/wiki/Carnosic_acid
[3] http://www.lvyinbio.com/plant-extract/carnosic-acid/
Chemical PropertiesYellow powder
DefinitionChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.
Anticancer ResearchCarnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).
Carnosic acid Preparation Products And Raw materials
Tag:Carnosic acid(3650-09-7) Related Product Information
SAGE OIL, SPANISH Dimethyl ether Glycine Carnosic acid CARNOSIC ACID STANDARD SAMPLE cyclomenol 1-(4-Methylphenyl)-1-cyclohexanecarboxylic acid DEHYDROABIETINE 1-Phenylcyclohexane-1-carbaldehyde pisiferic acid 1-PHENYL-1-CYCLOHEXANECARBOXYLIC ACID 3-ISOPROPYL-6-METHYLCATECHOL 2-CYCLOHEXYL-5-METHYLPHENOL (1-phenylcyclohexane)methanol 2 [PARA ISOPROPYL PHENYL] PROPIONALDEHYDE CARNOSOL phosphoric acid Ethyl 2-(Chlorosulfonyl)acetate