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| Product Name: | AFC | | Synonyms: | AFC;AC-CYSTEINE(FARNESYL)-OH;AC-CYS(FARNESYL)-OH;ACETYL-S-FARNESYL-L-CYSTEINE;N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE;N-ACETYL-S-FARNESYL-L-CYSTEINE;N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE;n-acetyl-s-farnesylcysteine | | CAS: | 135304-07-3 | | MF: | C20H33NO3S | | MW: | 367.55 | | EINECS: | | | Product Categories: | | | Mol File: | 135304-07-3.mol |  |
| Boiling point | 566.1±50.0 °C(Predicted) | | density | 1.038±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) | | form | Pale yellow oil. | | pka | 3.31±0.10(Predicted) | | color | Yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | LogP | 5.860 (est) |
| Description | N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins. | | Chemical Properties | Yellow-red oil | | Uses | Arazine is an FTS (trans-Farnesylthiosalicylic Acid) compound, which does not inhibit EJ cell growth and does not affect Ras. | | Definition | ChEBI: Acetyl-farnesyl-cysteine is a sesquiterpenoid. | | References | 1) Volker?et al.?(1991),?Effects of farnesylcyteine analogs on protein carboxyl methylation and signal transduction; J. Biol. Chem.?266?21515
2) Xu?et al.?(1996),?Inhibition of capacitative Ca2+ entry into cells by farnesyl analogs; Mol. Pharmacol.?50?1495
3) Rosado and Sage (2000),?Farnesylcyteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton; Biochem. J.?347?183
4) Gordon?et al.?(2008),?Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site; J. Invest. Dermatol.?128?643
5) Adhami?et al.?(2012),?N-acetyl-S-farnesyl-L-cysteine suppresses chemokine production by human dermal microvascular endothelial cells;?Exp. Dermatol.?21?700 |
| | AFC Preparation Products And Raw materials |
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