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Zoledronic acid

Zoledronic acid Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718 +86(0)13336195806
Email: sales@capotchem.com
Products Intro: Product Name:Zoledronic acid
CAS:118072-93-8
Purity:98% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Zoledronic acid
CAS:118072-93-8
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:zoledronic acid
CAS:118072-93-8
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:118072-93-8
CAS:118072-93-8
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:118072-93-8
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Zoledronic acid manufacturers

  • Zoledronic acid
  • $55.00-40.00 / KG
  • 2021-11-09
  • CAS:118072-93-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
  • Zoledronic acid
  • $1904.00 / Kg/Bag
  • 2021-11-02
  • CAS:118072-93-8
  • Min. Order: 1Kg/Bag
  • Purity: 99%
  • Supply Ability: 2000KG
  • zoledronic acid
  • $70.00 / KG
  • 2021-10-20
  • CAS:118072-93-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
Zoledronic acid Basic information
Product Name:Zoledronic acid
Synonyms:2-(imidazole-1-yl)-1-acetic acid HCl;CGP-42446;Zoledronic Acid API;sMall aMount;Aclasta;BPH 91;Orazol;Reclast
CAS:118072-93-8
MF:C5H10N2O7P2
MW:272.09
EINECS:1806241-263-5
Product Categories:TGF-beta/Smad;APIs;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical material and intermeidates;Bone resorption inhibitor;Antiosteoporotic;Zoledronate;Zoledronic;Smad;TGF-beta
Mol File:118072-93-8.mol
Zoledronic acid Structure
Zoledronic acid Chemical Properties
Melting point 193-2040C (dec)
Boiling point 764.0±70.0 °C(Predicted)
density 2.13±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka1.41±0.10(Predicted)
CAS DataBase Reference118072-93-8(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 21/22-36/37/38
Safety Statements 24/25-36/37/39
HS Code 2933399090
MSDS Information
Zoledronic acid Usage And Synthesis
DescriptionZoledronic acid is a white, crystalline powder that is available in vials for reconstitution for IV infusion over at least 15 minutes. It does not undergo metabolic transformation and does not inhibit CYP450 enzymes. Clearance of this agent is dependent on the patient's creatinine clearance, not on dose. Serum creatinine levels should be evaluated before every treatment. Zolendronic acid is contraindicated in patients with severe renal impairment.
Chemical PropertiesWhite Solid
OriginatorZometa,Novartis Pharma,Switz
UsesBisphosphonate antiresorptive agent
Usesbone resorption inhibitor
DefinitionChEBI: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Manufacturing ProcessWith stirring and under reflux, 8.6 g (0.053 mole) of imidazol-4-yl acetic acid hydrochloride, 7.1 ml of 85% phosphoric acid and 25 ml of chlorobenzene are heated to 100°C. Then 13.9 ml of phosphorus trichloride are added dropwise at 100°C, whereupon evolution of gas occurs. Over the course of 30 min a dense mass precipitates from the reaction mixture. The batch is heated for 3 hours to 100°C and the supernatant chlorobenzene is removed by decantation. With stirring and under reflux, the residual viscous mass is heated to the boil for 3 hours with 40 ml of 9 N hydrochloric acid. The batch is filtered hot with the addition of carbon and the filtrate is diluted with acetone, whereupon the crude 2-(imidazol-4-yl)-1-hydroxy-ethane-1,1- diphosphonic acid precipitates. This product is recrystallised from water. Melting point: 238-240°C (dec.).
Brand nameZometa (Novartis).
Therapeutic FunctionBone calcium regulator
Biological FunctionsZoledronic acid, a bisphosphonate, was approved by the U.S. FDA in 2001 for the treatment of hypercalcemia of malignancy, a metabolic complication that can be life-threatening. Hypercalcemia of malignancy can occur in up to 50% of patients diagnosed with advanced breast cancer, multiple myeloma, and nonsmall cell lung cancer. This condition arises when chemical moieties produced by the tumor cause overstimulation of osteoclasts. When there is an increase in bone degradation, there is a concomitant release of calcium into the plasma. When serum concentrations of calcium rapidly elevate, the kidneys are unable to handle the overload, and hypercalcemia results. This can lead to dehydration, nausea, vomiting, fatigue, and confusion. Zoledronic acid effectively decreases plasma calcium concentrations via inhibition of bone resorption (inhibition of osteoclastic activity and induction of osteoclast apoptosis). It also prevents the increase in osteoclastic activity caused by tumor-based stimulatory factors. Additionally zoledronic acid has been approved by the U.S. FDA for the treatment of multiple myeloma and bone metastases associated with solid tumor–based cancers (e.g., prostrate and lung). This agent is currently in late-stage clinical trials for the treatment and prevention of osteoporosis and, if approved, will be formulated as a 5-mg, once-yearly IV infusion.
Clinical UseZoledronic acid is most commonly given to patients whose cancer is no longer responding to hormones, but it also may be given to prevent the bone thinning and weakening that results from hormonal treatments.
Tag:Zoledronic acid(118072-93-8) Related Product Information
[15N2,13C2]-Zoledronic Acid Zoledronic Acid Trihydrate Zoledronic-d3 Acid ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE zoledronic acid hydrate,ZOLEDRONIC ACID MONOHYDRATE Rocuronium bromide Zofenoprilat Azamethiphos (1E)-2-cyano-2-[4-(1,1-diMethylethyl)phenyl]-1-(1,3,4-triMethyl-1H-pyrazol-5-yl)ethenyl 2,2-diMethylpropanoate 5-ethyl-6-octyl-[1,2,3]triazolo[1,5-a]pyriMidin-7-aMine Fenpyroximate TRIAZAMATE Oxazole-4-carboxylic acid [4-chloro-2-(hydroxymethyl)phenoxy]acetic acid Zoledronic Acid-D2 INTERMEDIATE OF ZOLEDRONIC ACID,IMIDAZOL-1-YLACETIC ACID HYDROCHLORIDE (INTERMEDIATE OF ZOLEDRONIC ACID) ZOLEDRONIC ACID-D3 2-(1H-imidazol-1-yl)acetic acid hydrochloride (intermediate of zoledronic acid)