CPD1589
中文名称 | CPD1589 |
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中文同义词 | 化合物 T13603;化合物CDDO-3P-IM |
英文名称 | CDDO-2-P-Im |
英文同义词 | Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(3-pyridinyl)-1H-imidazol-1-yl]-;CDDO-3P-Imidazolide;CPDB1589;CPD1589;CDDO-2-P-Im;CDDO 3P Im,CDDO3PIm |
CAS号 | 1883650-95-0 |
分子式 | C39H46N4O3 |
分子量 | 618.81 |
EINECS号 | |
相关类别 | |
Mol文件 | 1883650-95-0.mol |
结构式 |
CPD1589 性质
沸点 | 771.1±70.0 °C(Predicted) |
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密度 | 1.25±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:250 mg/mL(404.00 mM) |
形态 | 固体 |
酸度系数(pKa) | 3.34±0.12(Predicted) |
颜色 | 白色至米白色 |
CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 4.3 nM.
Apoptosis Analysis
Cell Line: | U937 cells |
Concentration: | 30 nM, 100 nM |
Incubation Time: | 4 days |
Result: | Induced differentiation of U937 cells at 30 nM. |
CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
Animal Model: | Seven week-old female A/J mice |
Dosage: | 50 mg/kg, 200 mg/kg |
Administration: | Diet; for 16 weeks |
Result: | Decreased the number, the size and the severity of tumors. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-126379 | CDDO-2P-Im | 1 mg | 1066元 | |
2024/08/19 | HY-126379 | CPD1589 CDDO-2P-Im | 1883650-95-0 | 5mg | 2800元 |