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Sigma-Aldrich
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| Products Intro: |
Product Name:Uridine 5'-triphosphate tris salt
CAS:108321-53-5
Purity:Type VI, >=90% Package:100MG Remarks:U6875-100MG
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| | URIDINE 5'-TRIPHOSPHATE TRIS SALT Basic information |
| | URIDINE 5'-TRIPHOSPHATE TRIS SALT Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble50mg/mL, clear, colorless |
| | URIDINE 5'-TRIPHOSPHATE TRIS SALT Usage And Synthesis |
| Uses | Uridine 5''-Triphosphate Tris Salt is a polyphosphate analogue of the nucleoside Uridine used in the preparation of potent and selective agonists at the G-protein-coupled P2Y receptors. | | Uses | Uridine 5′-triphosphate tris salt has been used:
- to investigate its activation potential on the purinergic?P2Y2 Receptor in THP1 monocytes
- as a component of non-radioactive nucleoside triphosphate solution used in in vitro RNA polymerase assay
- as a P2Y2 agonist in human embryonic kidney cells (HEK293T) in dynamic mass redistribution (DMR) assays
| | Biochem/physiol Actions | Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic?(P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway. |
| | URIDINE 5'-TRIPHOSPHATE TRIS SALT Preparation Products And Raw materials |
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