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| | Porcupine-IN-1 Basic information |
| Product Name: | Porcupine-IN-1 | | Synonyms: | Porcupine-IN-1;PORCN-IN-1;Porcn inhibitor 1;CS-2802;9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-;Porcupine-IN-1 free base;Porcupine,inhibit,PorcnIN1,Inhibitor,Porcn IN 1 | | CAS: | 2036044-77-4 | | MF: | C25H19FN4O | | MW: | 410.44 | | EINECS: | | | Product Categories: | | | Mol File: | 2036044-77-4.mol |  |
| | Porcupine-IN-1 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: slightly soluble | | form | A crystalline solid |
| | Porcupine-IN-1 Usage And Synthesis |
| Description | Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins. | | Uses | Porcupine-IN-1, is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. |
| | Porcupine-IN-1 Preparation Products And Raw materials |
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