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| | 5-Chloro-8-hydroxyquinoline Basic information |
| | 5-Chloro-8-hydroxyquinoline Chemical Properties |
| Melting point | 122-124 °C(lit.) | | Boiling point | 348.7±22.0 °C(Predicted) | | density | 1.2364 (rough estimate) | | vapor pressure | 0.003Pa at 25℃ | | refractive index | 1.5330 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | 0.019g/l (experimental) | | form | Powder | | pka | 3.77±0.10(Predicted) | | color | Light green to gray | | Sensitive | Light Sensitive | | Merck | 14,2422 | | BRN | 5289 | | InChIKey | RWPWQYXFGFYJBA-UHFFFAOYSA-N | | CAS DataBase Reference | 130-16-5(CAS DataBase Reference) | | NIST Chemistry Reference | 8-Quinolinol, 5-chloro-(130-16-5) | | EPA Substance Registry System | 8-Quinolinol, 5-chloro- (130-16-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | RTECS | VC4590000 | | TSCA | Yes | | HS Code | 29334990 |
| | 5-Chloro-8-hydroxyquinoline Usage And Synthesis |
| Chemical Properties | light green to grey powder | | Uses | Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug. | | Uses | antibacterial, antifungal | | Definition | ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x | | in vitro | Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells. | | in vivo | Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model. |
| | 5-Chloro-8-hydroxyquinoline Preparation Products And Raw materials |
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