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(S)-(-)-PROPRANOLOL HYDROCHLORIDE

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Products Intro: Product Name:(S)-(-)-Propranolol hydrochloride
CAS:4199-10-4
Purity:99% Package:1KG;1USD|25KG;15USD|100KG;45USD
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Products Intro: Product Name:(s)-(-)-Propranolol hydrochloride
CAS:4199-10-4
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CAS:4199-10-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:(S)-(-)-PROPRANOLOL HYDROCHLORIDE
CAS:4199-10-4
Purity:99% Package:5KG;1KG Remarks:C16H22ClNO2
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Products Intro: Product Name:(S)-(-)-Propranolol hydrochloride
CAS:4199-10-4
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(S)-(-)-PROPRANOLOL HYDROCHLORIDE manufacturers
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Basic information
Product Name:(S)-(-)-PROPRANOLOL HYDROCHLORIDE
Synonyms:2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2S)- (9CI);2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (S)-;L-(-)-Propranolol hydrochloride;l-Propranolol chlorhydrate;l-Propranolol hydrochloride;S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride;S-PROPANOLOL;(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
CAS:4199-10-4
MF:C16H22ClNO2
MW:295.8
EINECS:224-096-0
Product Categories:Adrenoceptor;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:4199-10-4.mol
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Structure
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Chemical Properties
Melting point 193-195 °C(lit.)
storage temp. 2-8°C
solubility ethanol: 10 mg/mL
form powder
color White to off-white
Optical Rotation[α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Water Solubility Soluble to 100 mM in water
BRN 3574966
InChIKeyZMRUPTIKESYGQW-UQKRIMTDSA-N
CAS DataBase Reference4199-10-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Usage And Synthesis
Description(S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. It is also a non-specific serotonin receptor antagonist. Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.
Chemical Properties(S)-(-)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Usesactive enantiomer, 5-HT1 receptor antagonist
UsesThe S-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
UsesAntihypertensor;Beta-adrenergic blocking agent
Biological ActivityMore active enantiomer of the β -adrenoceptor antagonist propranolol ((RS)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride ).
Biochem/physiol Actions(S)-(?)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(?)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.
storageStore at RT
Purification MethodsThe (+)-salt is the active isomer which blocks isoprenaline tachycardia and is a -adrenergic blocker. [Leclerc et al. Trends Pharmacol Sci 2 18 1981, Howe & Shanks Nature 210 1336 1966.]
References[1] D W COSTAIN  A R G. beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine.[J]. British Journal of Pharmacology, 1978, 64 2: 193-200. DOI: 10.1111/j.1476-5381.1978.tb17289.x
(S)-(-)-PROPRANOLOL HYDROCHLORIDE Preparation Products And Raw materials
Tag:(S)-(-)-PROPRANOLOL HYDROCHLORIDE(4199-10-4) Related Product Information
1-ETHOXYNAPHTHALENE (RS)-Propranolol hydrochloride,Propranolol Hydrochloride for pharmaceutical raw materials,DL-PROPRANOLOL HYDROCHLORIDE (S)-(-)-PROPRANOLOL HYDROCHLORIDE Propanolol 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98 2-(1-NAPHTHYLOXY) ETHANOL Propranolol hydrochloride R(+)-PROPRANOLOL HYDROCHLORIDE >98% (R)-4-Hydroxy Propranolol Hydrochloride,(S)-4-Hydroxy Propranolol Hydrochloride d-Propranolol hydrochloride,(R)-(+)-PROPRANOLOL HYDROCHLORIDE,(R)-PROPRANOLOL HYDROCHLORIDE (S)-3-AMINO-1,2-DIHYDROXYPROPANE HYDROCHLORIDE CHEMBRDG-BB 5482082 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL AKOS BBS-00007965 (S)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL 3-phenoxy-1-propanamine (S)-N-DESISOPROPYLPROPRANOLOL 1-AMINO-3-PHENOXY-PROPAN-2-OL
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