| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
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| | ANTI-MAD-3 Basic information |
| Product Name: | ANTI-MAD-3 | | Synonyms: | Anti-CSGALNACT2 antibody produced in rabbit;Anti-NFKBID antibody produced in rabbit;Anti-phospho-NFKBIA (pSer32/pSer36) antibody produced in rabbit;Anti-NFKBIB (AB1) antibody produced in rabbit;Monoclonal Anti-NFKBIA antibody produced in mouse;Anti-NFKBIA (ab2) antibody produced in rabbit;Anti-MXD3 (C-terminal) antibody produced in goat;Anti-NFKBIA (ab1) antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-MAD-3 Structure]() |
| | ANTI-MAD-3 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | Storage Class | 10 - Combustible liquids |
| | ANTI-MAD-3 Usage And Synthesis |
| Uses | Rabbit Anti-NFKBIB (AB1) can be used for western blot (5 μg/ml) and IHC (4-8 μg/ml) assays. | | General Description | NFKBIB is an NF-κB inhibitor that forms a complex with NF-κB and traps it in the cytoplasm. Serine phosphorylation in NFKBIB proteins activates its ubiquitin-mediated degradation. This subsequently facilitates the nuclear transport and functions of NF-κB proteins.
Rabbit Anti-NFKBIB antibody recognizes human, mouse, rat, canine, and bovine NFKBIB. | | Biochem/physiol Actions | NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]. |
| | ANTI-MAD-3 Preparation Products And Raw materials |
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