NAFTOPIDIL DIHYDROCHLORIDE manufacturers
- Naftopidil
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- $1.00 / 1g
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2020-01-13
- CAS:57149-08-3
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1ton
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| | NAFTOPIDIL DIHYDROCHLORIDE Basic information |
| Product Name: | NAFTOPIDIL DIHYDROCHLORIDE | | Synonyms: | NAFTOPIDIL 2HCL;4-(2-METHOXYPHENYL)-A-[(1-NAPHTHALENYLOXY)METHYL]-1-PIPERAZINEETHANOL, DIHYDROCHLORIDE;4-(2-METHOXYPHENYL)-ALPHA-([1-NAPHTHALENYLYOXY]METHYL)-1-PIPERAZINEETHANOL DIHYDROCHLORIDE;KT-611 DIHYDROCHLORIDE;4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol,2HCl;Naftopidil HCL;3-[(4-methylpiperazin-1-yl)methyl]quinazolin-4-one dihydrochloride;1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol dihydrochloride | | CAS: | 57149-08-3 | | MF: | C24H30Cl2N2O3 | | MW: | 465.41 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Flivas, KT-611, Avishot | | Mol File: | 57149-08-3.mol |  |
| | NAFTOPIDIL DIHYDROCHLORIDE Chemical Properties |
| Melting point | 212-213° | | storage temp. | Sealed in dry,Room Temperature | | solubility | methanol: >10 mg/mL | | form | solid | | color | white |
| WGK Germany | 3 | | RTECS | TL9336500 |
| | NAFTOPIDIL DIHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | A α-1-Adrenergic receptor antagonist, antihypertensive. | | Uses | Antihypertensive;Alpha1 agonist | | in vivo | Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].
| Animal Model: | Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2] | | Dosage: | 10 mg/kg | | Administration: | Oral administration, daily, for 28 days | | Result: | Decreased tumor weights. |
| | IC 50 | Alpha-1A adrenergic receptor: 3.7 nM (Ki); Alpha-1B adrenergic receptor: 20 nM (Ki); Alpha-1D adrenergic receptor: 1.2 (Ki) |
| | NAFTOPIDIL DIHYDROCHLORIDE Preparation Products And Raw materials |
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