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Pramlintide acetate

Pramlintide acetate Suppliers list
Tel: 18315825527
Products Intro: Product Name:Pramlintide Acetate
Purity:99% Package:1g/bottle; 5g/bottle;10g/bottle;67g/bottle Remarks:Pharmaceutical
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: 0086-411-39042497
Products Intro: Product Name:Pramlintide
Purity:99% Package:25mg; 50mg;250mg;Bulk
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Pramlintide acetate
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:196078-30-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Rixing Chemical CO.,LTD
Tel: 13237129059
Products Intro: Product Name:Pramlintide Acetate
Purity:98% Package:1gram/bottle;10g/bottle;100g/bottle;1kg/foilbag

Lastest Price from Pramlintide acetate manufacturers

  • Pramlintide acetate
  • US $7.00 / KG
  • 2019-07-10
  • CAS:196078-30-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
Pramlintide acetate Basic information
Product Name:Pramlintide acetate
Synonyms:AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE;pramlintide acetate;pramlintide acetate hydrate;Pramlintide Acetate, Amylin Rat;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;Tripo-aMylin Acetate Hydrate
Product Categories:Peptide;Amino Acids & Derivatives;Bases & Related Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
Mol File:196078-30-5.mol
Pramlintide acetate Structure
Pramlintide acetate Chemical Properties
CAS DataBase Reference196078-30-5(CAS DataBase Reference)
Safety Information
MSDS Information
Pramlintide acetate Usage And Synthesis
DescriptionPramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.
Chemical PropertiesPramlintide acetate is White Solid
OriginatorAmylin (US)
UsesPramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.
Brand nameSymlin (Amylin).
Pramlintide acetate Preparation Products And Raw materials
Tag:Pramlintide acetate(196078-30-5) Related Product Information
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