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DL-Threonine

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Products Intro: Product Name:DL-Threonine
CAS:80-68-2
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
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CAS:80-68-2
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
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Products Intro: Product Name:DL-Threonine
CAS:80-68-2
Purity:99% Package:100g;500g;1kg;25kg...
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Products Intro: Product Name:DL-Thr
CAS:80-68-2
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from DL-Threonine manufacturers

  • DL-Threonine
  • US $0.00 / Kg/Drum
  • 2021-10-22
  • CAS:80-68-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200mt/year
  • DL-Threonine
  • US $0.00 / Kg/Drum
  • 2021-09-29
  • CAS:80-68-2
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 500kgs
  • DL-Threonine
  • US $1.00 / KG
  • 2019-07-06
  • CAS:80-68-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton
DL-Threonine Basic information
Chemical properties Uses Content analysis Toxicity
Product Name:DL-Threonine
Synonyms:H-DL-THR-OH;DL-AMINO-HYDROXYBUTYRIC ACID;DL-ALPHA-AMINO-BETA-HYDROXYBUTYRIC ACID;ALLOTHREONINE, DL-(RG);THREONINE(allo-free), DL-(RG);DL-Threonin;dl-tthreonine;H-DL-Thr-OH (DL-Threonine)
CAS:80-68-2
MF:C4H9NO3
MW:119.12
EINECS:201-300-6
Product Categories:amino acid;Amino Acids;Amino Acids;Threonine [Thr, T];alpha-Amino Acids;Biochemistry;Amino Acid Derivatives
Mol File:80-68-2.mol
DL-Threonine Structure
DL-Threonine Chemical Properties
Melting point 244 °C (dec.)(lit.)
Boiling point 222.38°C (rough estimate)
alpha [α]D20 0±1.0゜ (c=6, H2O)
density 1.3126 (rough estimate)
refractive index 1.4183 (estimate)
storage temp. Store at RT.
pka2.09(at 25℃)
form Powder
color White
Water Solubility 200 g/L (25 ºC)
Merck 14,9380
BRN 1721647
CAS DataBase Reference80-68-2(CAS DataBase Reference)
NIST Chemistry ReferenceDL-Threonine(80-68-2)
EPA Substance Registry SystemThreonine (80-68-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-37/39-26
WGK Germany 3
TSCA Yes
HS Code 29225000
MSDS Information
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DL-Threonine English
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DL-Threonine Usage And Synthesis
Chemical propertiesBecause of the 2 asymmetric carbon atoms contained in the threonine molecule there are D-threonine, L-threonine, D-doxylthreonine and L-doxylthreonine, four kinds of optical isomers, of which the amino acids constituting the protein is L-threonine while the other three optical isomers can not be used.
DL-threonine appears as white crystalline or crystalline powder, being odorless with slightly sweet taste. The melting point is about 245 ° C (decomposition). It can be dissolved in water (20.1g/100mL, 25 ° C), being insoluble in organic solvents such as ethanol. It has stable chemical property. Rats-intraperitoneally injection-LD50: 5.355 g/kg (type D).
L-threonine [72-19-5] has a melting point of about 256 ℃ (decomposition) with the physiological effect of the DL-type being 2 times of that of the DL-type. Rats subjecting to intraperitoneal injection has a LD50 of 3.094g/kg. The rest is the same as the DL type.
Uses1.Threonine is a feed nutrient enhancer, being the essential amino acids for the growth of livestock and poultry fish. It is mainly added to wheat, barley and other cereal-based feed.
2. For biochemical research.
3. It can be used as nutritional supplements. Requirement amount (mg/k/D): 60 to 87 for children, 310 to 560 for adults with great variance and is still affected by total protein in food and amino acids.
4. The first limiting amino acid for rice, wheat, bread, corn, etc. is glycine, which may be supplemented with a secondary restricted amino acid, threonine. It can still strengthen the peanut powder, oats and so on.
5. In order to exert the best efficacy, it can be co-used with glycine in rice, and co-used in wheat flour together with glycine and valine, and co-used with glycine and methionine in barley, oats, and co-used with glycine and tryptophan in corn.
6. It is easy to produce coke aroma and chocolate aroma upon co-heating with glucose. It has aromatherapy role.
7. L-threonine ([72-19-5]) is essential amino acids with the physiological effect of DL-threonine being half of that of the L-threonine. Upon its lack, people is easily susceptible to loss of appetite and fatty liver embolism. Threonine can not be de novo synthesized inside the higher animals body and must be supplied externally. The cereal protein, in addition to should being provided of L-lysine, should also be supplied with L-threonine. This is due to that although there is a high content of L-threonine, but the combination of threonine and peptide in the protein is difficult to be hydrolyzed and is not easily digested and absorbed. As a nutritional supplement, in order to play the best use of fruit, it can be co-used with glycine in the rice, co-used with glycine and valine in wheat flour, and co-used with glycine and methionine in the barley, oats as well as co-used with glycine and tryptophan in corn. Co-heating with hot grapes can easily produce empyreumatique and chocolate flavor with aromatherapy role. It can also be used for separation to obtain L-threonine and further for the preparation of amino acid infusion and integrated amino acid preparations.
Content analysisIt is the same as the content analysis method of "DL-alanine". Every mL of 0.1mol/L perchloric acid solution is equivalent to 11.91 mg of DL-threonine (C4H9NO3).
ToxicityL-type: LD50: 26mmol/kg (rat, intraperitoneal injection); D-type: LD50 45mmol/kg (rat, intraperitoneal injection). It can be safely applied to food products (FDA, §172.320, 2000).
DescriptionThreonine (abbreviated as Thr or T) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(OH)CH3. Its codons are ACU, ACA, ACC, and ACG. This essential amino acid is classified as polar. Together with serine, threonine is one of two proteinogenic amino acids bearing an alcohol group (tyrosine is not an alcohol but a phenol, since its hydroxyl group is bonded directly to an aromatic ring, giving it different acid/base and oxidative properties). It is also one of two common amino acids that bear a chiral side chain, along with isoleucine.
The threonine residue is susceptible to numerous posttr anslational modifications. The hydroxy side-chain can undergo Olinked glycosylation. In addition, threonine residues undergo phospho rylation through the action of a threonine kinase. In its phosphorylated form, it can be referred to as phospho threonine.
Chemical PropertiesWhite crystalline powder
OccurrenceFoods high in threonine include cottage cheese, poultry, fish, meat, lentils, Black turtle bean and Sesame seeds.
Racemic threonine can be prepared from crotonic acid by alphafunctionalization using mercury (II) acetate.
HistoryThreonine was discovered as the last of the 20 common proteinogenic amino acids in the 1930s by William Cumming Rose.
Brand nameL -Threonine is JAN.
BiosynthesisAs an essential amino acid, threonine is not synthesized in humans, hence we must ingest threonine in the form of threoninecontaining proteins. In plants and microorganisms, threonine is synthesized from aspartic acid via α-aspartyl-semialdehyde and homoserine. Homoserine undergoes O-phosphorylation; this phosphate ester undergoes hydrolysis concomitant with relocation of the OH group. Enzymes involved in a typical biosynthesis of threonine include :
aspartokinase
β-aspartate semialdehyde dehydrogenase
homoserine dehydrogenase
homoserine kinase
threonine synthase.
Synthesis Reference(s)Tetrahedron Letters, 32, p. 1031, 1991 DOI: 10.1016/S0040-4039(00)74479-0
The Journal of Organic Chemistry, 63, p. 3499, 1998 DOI: 10.1021/jo9722717
MetabolismThreonine is metabolized in two ways:
It is converted to pyruvate via threonine dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to produce acetyl-CoA and glycine.
In humans, it is converted to α-ketobutyrate in a less common pathway via the enzyme serine dehydratase, and thereby enters the pathway leading to succinyl-CoA.
.
StereoisomerismThreonine is one of two proteinogenic amino acids with two chiral centers. Threonine can exist in four possible stereo isomers with the following configurations: (2S,3R), (2R,3S), (2S,3S) and (2R,3R). However, the name L-threonine is used for one single diastereomer, (2S,3R)-2-amino-3-hydroxybutanoic acid. The second stereoisomer (2S,3S), which is rarely present in nature, is called L-allo-threonine. The two stereo isomers (2R,3S)- and (2R,3R)-2-amino-3-hydroxy butanoic acid are only of minor importance.
DL-Threonine Preparation Products And Raw materials
Raw materialsGlycine-->L-Glutamic acid-->Potassium bromide-->Casein-->Crotonaldehyde-->L-Threonine-->Crotonic acid-->MERCURIC ACETATE-->L-Homoserine-->Copper glycinate
Preparation ProductsL-Threonine-->D-Threonine
Tag:DL-Threonine(80-68-2) Related Product Information
Threonine (Dl-Threonine) N-TFA-DL-THREONINE METHYL ESTER,N-Trifluoroacetyl-DL-threonine methyl ester N-[[5-(dimethylamino)-1-naphthyl]sulphonyl]-DL-threonine, compound with piperidine (1:1) DL-Threonine AJI92 N-CARBAMYL-DL-THREONINE POTASSIUM CRYSTA LLINE DL-Threonine ethyl ester hydrochloride H-DL-THR-OME·HCL, DL-THREONINE METHYL ESTER HYDROCHLORIDE Dl-Threonine(Threonine) COPPER-DL-THREONINE.ACETALDEHYDE N-(2,4-DINITROPHENYL)-DL-THREONINE,N-DNP-DL-THREONINE PHENYLTHIOHYDANTOIN-DL-THREONINE,PTH-DL-THREONINE,PTH-DL-Threonine Phenylthiohydantoin-DL-threonine DL-THREONINE (AJI90) DL-THREONINE.FORMALDEHYDE 4-(4-Aminophenyl)butyric acid METHYL 4-(4-AMINOPHENYL)BUTANOATE 3-Hydroxybutyric acid 3-Aminopyridine DL-4-Amino-3-hydroxybutyric acid