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Shanghai Rechem science Co., Ltd.
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| Products Intro: |
Product Name:(R)-ADX-47273
CAS:851881-59-9
Purity:0.98 Package:100mg;500mg;1g
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| | (R)-ADX-47273 Basic information |
| Product Name: | (R)-ADX-47273 | | Synonyms: | (R)-ADX-47273;(4-Fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]methanone;Methanone, (4-fluorophenyl)[(3R)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-;Inhibitor,inhibit,mGluR,(R)ADX47273,(R) ADX 47273,Metabotropic glutamate receptors | | CAS: | 851881-59-9 | | MF: | C20H17F2N3O2 | | MW: | 369.36 | | EINECS: | | | Product Categories: | | | Mol File: | 851881-59-9.mol |  |
| | (R)-ADX-47273 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | (R)-ADX-47273 Usage And Synthesis |
| Description | (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
mGluR5|168 nM (EC50)
(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1]. | | References | [1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11. |
| | (R)-ADX-47273 Preparation Products And Raw materials |
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