| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:M-525
CAS:2173582-08-4
Purity:98% HPLC LCMS Package:100mg;500mg;1g
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M-525
(M525) manufacturers
- M-525 (M525)
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- $30.00 / 1kg
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2023-09-08
- CAS:2173582-08-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000t/year
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| | M-525
(M525) Basic information |
| Product Name: | M-525
(M525) | | Synonyms: | M-525
(M525);Carbamic acid, N-[(1S,2R)-2-[(S)-cyano[1-[[1-[4-[[1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-azetidinyl]sulfonyl]phenyl]-3-azetidinyl]methyl]-4-piperidinyl](3-fluorophenyl)methyl]cyclopentyl]-, methyl ester | | CAS: | 2173582-08-4 | | MF: | C39H51FN6O5S | | MW: | 734.92 | | EINECS: | | | Product Categories: | | | Mol File: | 2173582-08-4.mol |  |
| | M-525
(M525) Chemical Properties |
| Boiling point | 902.3±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | pka | 11.70±0.40(Predicted) |
| | M-525
(M525) Usage And Synthesis |
| Description | M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction. | | Uses | M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC50 of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity[1]. | | References | [1] Xu S, et al. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. DOI:10.1002/anie.201711828 |
| | M-525
(M525) Preparation Products And Raw materials |
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