WYC-209 manufacturers
- WYC-209
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- $55.00 / 5mg
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2025-04-29
- CAS:2131803-90-0
- Min. Order:
- Purity: 99.77%
- Supply Ability: 10g
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| | WYC-209 Basic information |
| Product Name: | WYC-209 | | Synonyms: | WYC-209;5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester;Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209 | | CAS: | 2131803-90-0 | | MF: | C20H20N2O3S | | MW: | 368.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2131803-90-0.mol |  |
| | WYC-209 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (226.16 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | color | Light yellow to yellow |
| | WYC-209 Usage And Synthesis |
| Uses | WYC-209 RAR Agonist is used in the preparation of the retinoid compounds and their application as anticancer agents. | | Biological Activity | Synthetic retinoid with antiproliferative activity', 'WYC-209 is a synthetic retinoid with antiproliferative activity and better inhibition of cancer cell growth and proliferation than Tazarotene or ATRA (all-trans-retinoic acid). WYC-209 was shown to inhibit proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with an IC50 value of 190 nM and also inhibited proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture. | | in vivo | WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases[1]. | Animal Model: | Female immune-competent C57BL/6 mice[1] | | Dosage: | 0.022, 0.22?mg/kg | | Administration: | Intravenous injection; once every two days for 25 days | | Result: | Four out of eight mice formed lung metastases at dose of 0.022?mg?/kg, only one out of eight mice formed lung metastases at dose of 0.22?mg/kg. |
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| | WYC-209 Preparation Products And Raw materials |
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