乙氢去甲奎宁
| 中文名称 | 乙氢去甲奎宁 |
|---|---|
| 中文同义词 | 乙氢去甲奎宁;乙基氢化脱甲奎宁;乙基氢化铜色金鸡纳碱;乙基氢化铜色树碱;(R)-(6-乙氧基喹啉-4-基)((1S,2S,4S,5R)-5-乙基奎宁-2-基)甲醇;化合物 ETHYLHYDROCUPREINE |
| 英文名称 | Ethylhydrocupreine |
| 英文同义词 | optochin;optoquine;ethylhydrocupreine free base*crystalline;Numoquine;Optochine;Hydrocupureine ethyl ether;Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8a,9R)-;6’-ethoxy-10,11-dihydro-,(8-alpha,9r)-cinchonan-9-o |
| CAS号 | 522-60-1 |
| 分子式 | C21H28N2O2 |
| 分子量 | 340.46 |
| EINECS号 | 208-333-5 |
| 相关类别 | 乙氢去甲奎宁;Miscellaneous |
| Mol文件 | 522-60-1.mol |
| 结构式 |  |
乙氢去甲奎宁 性质
| 熔点 | 123-128° when solvent-free |
|---|---|
| 比旋光度 | D25 -136.2° (alcohol) |
| 沸点 | 476.25°C (rough estimate) |
| 密度 | 1.1027 (rough estimate) |
| 折射率 | 1.6180 (estimate) |
| 储存条件 | 2-8°C |
S. pneumoniae
IC50: 25.75 nM (
Plasmodium falciparum
)
ggTas2r1,
ggTas2r2 and ggTas2r7
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
| 提供商 | 语言 |
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英文
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