1-甲基-4-苯基吡啶鎓碘化物
| 中文名称 | 1-甲基-4-苯基吡啶鎓碘化物 |
|---|---|
| 中文同义词 | 1-甲基-4-苯基吡啶离子;MPP+碘;碘化-N-甲基-4-苯基吡啶盐;N-甲基-4-苯基吡啶鎓碘化物;1-甲基-4-苯基吡啶鎓碘化物;1-甲基-4-苯基吡啶碘化物;MPP+碘化物;1-甲基-4-苯基吡啶 |
| 英文名称 | MPP+ IODIDE |
| 英文同义词 | N-Methyl-4-phenylpyridinium iodide;Pyridinium, 1-methyl-4-phenyl-, iodide;MPP+ iodide,1-Methyl-4-phenylpyridinium iodide;1-methyl-4-phenyl-pyridiniuiodide;MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX;4-phenylpyridin-1-ium iodide;MPP+ IODIDE ISO 9001：2015 REACH;1-methyl-4-phenylpyridin-1-ium |
| CAS号 | 36913-39-0 |
| 分子式 | C12H12IN |
| 分子量 | 297.13485 |
| EINECS号 | |
| 相关类别 | 合成;化合物;生物活性分子;Aromatics;Heterocycles;Mutagenesis Research Chemicals;Neurochemicals |
| Mol文件 | 36913-39-0.mol |
| 结构式 |  |
1-甲基-4-苯基吡啶鎓碘化物 性质
| 熔点 | 166-168 °C |
|---|---|
| 储存条件 | desiccated |
| 溶解度 | 可溶于0.1MHCl |
| 形态 | 固体 |
| 颜色 | 粘黄色 |
| InChIKey | RFDFRDXIIKROAI-UHFFFAOYSA-M |
MPP+ iodide 是神经毒素 MPTP 的一种有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。MPP+ iodide 被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。MPP+ iodide 也是 5-羟色胺转运体 (SERT) 的高亲和力底物。
MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells.
MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.
Cell Viability Assay
| Cell Line: | SH-SY5Y cells |
| Concentration: | 1, 2, 3 mM |
| Incubation Time: | 24 hours |
| Result: | SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner. |
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 23/24/25-36/37/38-25 |
| 安全说明 | 26-36-45 |
| 危险品运输编号 | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | UU6580000 |