ChemicalBook > Product Catalog >API >Diagnostic agents >Medical Imaging Drugs >IOCETAMIC ACID (200 MG)

IOCETAMIC ACID (200 MG)

IOCETAMIC ACID (200 MG) Suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:3-(N-(3-Amino-2,4,6-triiodophenyl)acetamido)-2-methylpropanoic acid
CAS:16034-77-8
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-36398
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:IOCETAMIC ACID (200 MG) USP/EP/BP
CAS:16034-77-8
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Shaanxi Dideu Newmaterial Co., Ltd.  
Tel: 029-87576359 15353716720
Email: 1039@dideu.com
Products Intro: Product Name:3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid
CAS:16034-77-8
Purity:99% Package:1KG
Company Name: Leancare Ltd.  
Tel: +33 962096793
Email: enquiry@leancare.co.uk
Products Intro:
Company Name: 2A PharmaChem USA  
Tel: (630) 737-0988
Email: sales@2apharmachem.com
Products Intro:
IOCETAMIC ACID (200 MG) Basic information
Product Name:IOCETAMIC ACID (200 MG)
Synonyms:3-[Acetyl(3-amino-2,4,6-triiodophenyl)amino]-2-methylpropionic acid;n-acetyl-n-(3-amino-2,4,6-triiodophenl)-2-methyl-beta-alanine;n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanin;n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-2-methyl-beta-alanine;n-acetyl-n-(3-amino-2,4,6-triiodophenyl)-beta-aminoisobutyricacid;IOCETAMIC ACID (200 MG);3-(acetyl(3-amino-2,4,6-triiodophenyl)amino)-2-methyl-propanoicaci;3-(acetyl-(3-amino-2,4,6-triiodophenyl)amino)-2-methylpropanoicacid
CAS:16034-77-8
MF:C12H13I3N2O3
MW:613.96
EINECS:240-173-1
Product Categories:
Mol File:16034-77-8.mol
IOCETAMIC ACID (200 MG) Structure
IOCETAMIC ACID (200 MG) Chemical Properties
Melting point 224-225° (NL 6515305); mp range 191-212° (Korver); Consists of 2 isomers having mps 232° and 200-201°
Boiling point 658.2±55.0 °C(Predicted)
density 2.2000 (rough estimate)
refractive index 1.7400 (estimate)
pka4.0(at 25℃)
Water Solubility 5.286g/L(37 ºC)
Stability:Stable. Incompatible with strong oxidizing agents.
Safety Information
Hazardous Substances Data16034-77-8(Hazardous Substances Data)
ToxicityLD50 in rats (g/kg): 7.1 orally; 0.70 i.v. (Janbroers)
MSDS Information
IOCETAMIC ACID (200 MG) Usage And Synthesis
OriginatorCholebrine,Nicholas
UsesDiagnostic aid (radiopaque medium).
DefinitionChEBI: 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid is an aromatic amide.
Manufacturing ProcessA mixture of equimolecular amounts of m-nitraniline (69.0 g), methacrylic acid (43.0 g), and pyridine (39.5 g) was heated to 125°C for 20 h, and was then poured into 500 ml water. A semi-crystalline product separated from the liquid. The supernatant liquid was decanted and 500 ml fresh water was added. The pH was adjusted to 7-7.5 by means of sodium hydroxide. The precipitate was filtered with suction and washed with water. When the filtrate was acidified with acetic acid, a precipitate of N-(3-nitrophenyl)-β-aminoisobutyric acid was formed. When filtered, washed with water and dried, it weighed 56.0 g and had a melting point of 130°-131°C (recryst. from alcohol). The yield was 50% based on nitraniline.
0.25 mol (56.0 g) N-(3-nitrophenyl)-β-aminoisobutyric acid, prepared as described above, 160 ml glacial acetic acid, and 40 ml acetic anhydride were heated 48 h to 50°C, and the reaction mixture was poured into 600 ml water. A crystalline precipitate of N-acetyl-N-(3-nitrophenyl)-β-aminoisobutyric acid formed gradually. When recovered, it weighed 56.0 g (84% yield). Melting point 146°-148°C.
100.0 g N-acetyl-N-(3-nitrophenyl)-β-amino-isobutyric acid were dissolved in 1 L water and 40 ml 25% aqueous ammonia, and the solution was hydrogenated in the presence of about 10.0 g Raney nickel at 20°C and about 450 p.s.i. until the pressure drop indicated the complete conversion of the NO2 groups to NH2. Thus N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was obtained.
The solution of N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was filtered after standing overnight, mixed with an equal volume of acetic acid, and there after with a solution of 275.0 g iodine monochloride and 200.0 g sodium chloride in 1 L water. The mixture was kept at 50°C with stirring for 48 h. Light brown crystals of crude N-acetyl-N-(2,4,6-triiodo-3-aminophenyl)- β-amino-isobutyric acid precipitated, were filtered off, washed with water, and dried. They weighed 195.0 g (84.5% yield based on N-acetyl-N 3-nitrophenylp-amino-isobutyric acid).
Brand nameCholebrine (Mallinckrodt).
Therapeutic FunctionDiagnostic aid
HazardLow toxicity by ingestion.
IOCETAMIC ACID (200 MG) Preparation Products And Raw materials
Raw materialsMethacrylic acid-->Pyridine-->3-Nitroaniline-->Sodium chloride
Tag:IOCETAMIC ACID (200 MG)(16034-77-8) Related Product Information
IOCETAMIC ACID (200 MG) 3-(2-IODOPHENYLAMINO)PROPANOIC ACID