| Company Name: |
Hubei Jusheng Technology Co.,Ltd. |
| Tel: |
18871490254 |
| Email: |
linda@hubeijusheng.com |
| Products Intro: |
Product Name:(4R,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
CAS:14206-58-7
Purity:0.99 Package:5KG;1KG Remarks:C22H24N2O9
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| | 4-Epioxytetracycline Basic information |
| Product Name: | 4-Epioxytetracycline | | Synonyms: | 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97;4-Epioxytetracycline, 'can be used as secondary standard', 97%;4-Epioxytetracycline,97%,'can be used as secondary standard';4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY ST;[4R-(4α,4aβ,5β,5aβ,6α,12aβ]-;Oxytetracycline IMpurity A;4-EPIOXYTETRACYCLINE;Oxytetracycline EP Impurity A/4-epi-Oxytetracycline | | CAS: | 14206-58-7 | | MF: | C22H24N2O9 | | MW: | 460.43 | | EINECS: | 204-888-2 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Chiral Reagents | | Mol File: | 14206-58-7.mol |  |
| | 4-Epioxytetracycline Chemical Properties |
| Melting point | 168°C | | Boiling point | 839.6±65.0 °C(Predicted) | | density | 1.71±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO: slightly soluble; Methanol: slightly, heated | | pka | 4.50±1.00(Predicted) | | form | Powder | | color | Greenish-beige to brownish | | Stability: | Hygroscopic, Light Sensitive, Unstable in Solution | | EPA Substance Registry System | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6S,12aS)- (14206-58-7) |
| | 4-Epioxytetracycline Usage And Synthesis |
| Description | Epioxytetracycline is a metabolite of Oxytetracycline. It has been found in swine manure compost and wastewater and is considered a pollutant. This highly pure metabolite can be used as a secondary reference standard during stability studies of oxytetracycline. It can also be used to study the degradation pathway and products of tetracyclines. | | Chemical Properties | greenish-beige to brownish powder | | Uses | Epioxytetracycline is a degradation product of oxytetracycline formed by the epimerisation of the dimethylamino group at C4 in solution at neutral to acidic pH. The epimerisation is associated with a loss of antibiotic activity. Epioxytetracycline is an important standard for monitoring oxytetracycline stability. | | Mode of action | Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.
In an acellular model system of protein synthesis using ribosomes from tetracycline-sensitive and resistant strains of E. coli in the synthesis of polyphenylalanine, Oxytetracycline showed inhibitory activity along with minocycline. 4-Epioxytetracycline and beta-apo-oxytetracycline had competing properties with respect to oxytetracycline at the stage of penetration through the cell membrane but did not, however, suppress the synthesis of polyphenylalanine. | | References | 1] I V BELIAVSKAIA. [Study of the mechanism of action of minocycline and of certain other tetracycline group compounds].[J]. Antibiotiki, 1976, 21 3: 242-245.
[2] BENT HALLING-S?RENSEN J. T G Sengel?v. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42 1: 263-271. DOI:10.1007/s00244-001-0017-2.
[3] ANNE KRUSE LYKKEBERG . Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS[J]. Journal of pharmaceutical and biomedical analysis, 2004, 34 2: Pages 325-332. DOI:10.1016/S0731-7085(03)00500-4.
[4] RICHENG XUAN. Hydrolysis and photolysis of oxytetracycline in aqueous solution.[J]. Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 2010, 45 1: 73-81. DOI:10.1080/03601230903404556.
[5] HONGXING HAN. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats[J]. Scientific Reports, 2016, 6 1. DOI:10.1038/srep23141. |
| | 4-Epioxytetracycline Preparation Products And Raw materials |
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