| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:Microcystin-LA
CAS:96180-79-9
Purity:10ug/ml in methanol Package:1ml/RMB 2883.90
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Microcystin LA from algae
CAS:96180-79-9
Purity:cyanotoxin Package:500UG Remarks:M4194-500UG
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Microcystin-LA
CAS:96180-79-9
Purity:10ug/ml in methanol Package:1ml Remarks:Y54357
|
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| | MICROCYSTIN LA Basic information |
| Product Name: | MICROCYSTIN LA | | Synonyms: | Microcystin-leucine-alanine;cyanoginosin-la;toxinbe4;Toxin be 4 (microcystis aeruginosa);DIAQQISRBBDJIM-DRSCAGMXSA-N;Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl];Certified Calibration Solution for Microcystin-LA | | CAS: | 96180-79-9 | | MF: | C46H67N7O12 | | MW: | 910.064 | | EINECS: | | | Product Categories: | Natural Products | | Mol File: | 96180-79-9.mol |  |
| | MICROCYSTIN LA Chemical Properties |
| | MICROCYSTIN LA Usage And Synthesis |
| Description | Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM. | | Uses | Microcystin LA from algae has been used as a standard for liquid chromatography/mass spectrometry (LCMS) for toxin analysis. | | Definition | ChEBI: Microcystin la is a peptide. | | General Description | Microcystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin. Microcystin has four congeners namely, -LR, -LA, -YR and -RR. | | Biochem/physiol Actions | Microcystin LA inhibits protein phosphatase type 2A and protein phosphatase type 3 more potently than protein phosphatase type 1 (order of potency PP2A > PP3 > PP1). Induces neutrophil-activating chemokines and extracellular reactive oxygen species, possible mechanisms of its hepatotoxic effects. | | References | [1] J B AGGEN. The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity.[J]. Bioorganic & Medicinal Chemistry, 1999, 7 3: 543-564. DOI: 10.1016/s0968-0896(98)00254-5
[2] NEIL CHERNOFF. Dose-Response Study of Microcystin Congeners MCLA, MCLR, MCLY, MCRR, and MCYR Administered Orally to Mice.[J]. ACS Applied Electronic Materials, 2021. DOI: 10.3390/toxins13020086
[3] MOURAD SKAFI . Occurrence of microcystins, anabaenopeptins and other cyanotoxins in fish from a freshwater wildlife reserve impacted by harmful cyanobacterial blooms[J]. Toxicon, 2021, 194: Pages 44-52. DOI: 10.1016/j.toxicon.2021.02.004 |
| | MICROCYSTIN LA Preparation Products And Raw materials |
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