OLOMOUCINE II

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Olomoucine II
CAS:500735-47-7
Purity:99.94% Package:1mg;159USD
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Products Intro: Product Name:Olomoucine II
CAS:500735-47-7
Purity:>=98% Package:$38.9/1mg;$90.9/5mg;Bulk package Remarks:98%
Company Name: NANJING YINGWEN BIOTECHNOLOGY CO LTD
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Products Intro: CAS:500735-47-7
Purity:98%
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Products Intro: Product Name:Olomoucine II - CAS 500735-47-7 - Calbiochem
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
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Products Intro: Product Name:Olomoucine II
CAS:500735-47-7
Purity:98% Package:1mg;5mg

OLOMOUCINE II manufacturers

  • Olomoucine II
  • Olomoucine II pictures
  • $159.00 / 1mg
  • 2025-12-22
  • CAS:500735-47-7
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  • Purity: 99.94%
  • Supply Ability: 10g
OLOMOUCINE II Basic information
Product Name:OLOMOUCINE II
Synonyms:Nsc736738;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Olomoucine II - CAS 500735-47-7 - Calbiochem;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-;Olomoucine II, CDK/cyclin inhibitor
CAS:500735-47-7
MF:C19H26N6O2
MW:370.45
EINECS:
Product Categories:
Mol File:500735-47-7.mol
OLOMOUCINE II Structure
OLOMOUCINE II Chemical Properties
Boiling point 618.5±65.0 °C(Predicted)
density 1.32
storage temp. −20°C
solubility chloroform: 50 mg/mL, soluble
form powder
pka9.83±0.30(Predicted)
color colorless
InChI1S/C19H26N6O2/c1-4-14(10-26)22-19-23-17(20-9-13-7-5-6-8-15(13)27)16-18(24-19)25(11-21-16)12(2)3/h5-8,11-12,14,26-27H,4,9-10H2,1-3H3,(H2,20,22,23,24)
InChIKeyNDUVSANREQEDRE-UHFFFAOYSA-N
Safety Information
Safety Statements 22-24/25
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
OLOMOUCINE II Usage And Synthesis
UsesOlomoucine II is a potent CDK inhibitor with IC50 values of 0.06, 0.1, 0.45, 7.6, 19.8 μM for CDK9/cyclin T, CDK2/cyclin E, CDK7/cyclin H, CDK1/cyclin B, CDK4/cyclin D1, respectively. Olomoucine II shows antiproliferative activity[1].
DefinitionChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.
General DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).
Biochem/physiol ActionsCell permeable: yes
IC 50CDK9/cycT: 0.06 μM (IC50); CDK2/cyclinE: 0.1 μM (IC50); CDK7/cyclin H: 0.45 μM (IC50); Cdk1/cyclin B: 7.6 μM (IC50); CDK4/cyclinD1: 19.8 μM (IC50)
References[1] Krystof V, et al. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci. 2005 Aug;62(15):1763-71. DOI:10.1007/s00018-005-5185-1
OLOMOUCINE II Preparation Products And Raw materials
Tag:OLOMOUCINE II(500735-47-7) Related Product Information
Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE AMINOPURVALANOL A SU 9516 NU6102 OLOMOUCINE